Injectable bone using chitosan-alginate gel/mesenchymal stem cells/BMP-2 composites

Dong Joon Park, Byung Ho Choi, Shi Jiang Zhu, Jin Young Huh, Byung Young Kim, Seoung Ho Lee

Research output: Contribution to journalArticlepeer-review

128 Citations (Scopus)


Aim: Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation. Material and methods: The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period. Results: The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type. Conclusions: This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalJournal of Cranio-Maxillofacial Surgery
Issue number1
Publication statusPublished - 2005 Feb

Bibliographical note

Funding Information:
This work was supported by grant No. Rl3-2003-13 from the Medical Science and Engineering Research Program of the Korea Science & Engineering Foundation.

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology


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