Abstract
Aim: Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation. Material and methods: The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period. Results: The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type. Conclusions: This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone.
| Original language | English |
|---|---|
| Pages (from-to) | 50-54 |
| Number of pages | 5 |
| Journal | Journal of Cranio-Maxillofacial Surgery |
| Volume | 33 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2005 Feb |
Bibliographical note
Funding Information:This work was supported by grant No. Rl3-2003-13 from the Medical Science and Engineering Research Program of the Korea Science & Engineering Foundation.
All Science Journal Classification (ASJC) codes
- Surgery
- Oral Surgery
- Otorhinolaryngology