Initial topical monotherapy may increase the risk of recurrence in patients with extramammary Paget’s disease

Sooyie Choi, Yeongjoo Oh, Mi Ryung Roh, Kee Yang Chung, Byung Ho Oh

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1 Citation (Scopus)


Although topical therapies are used to treat extramammary Paget's disease (EMPD), reliable treatment outcomes and the effects of these therapies on subsequent surgical treatments are unclear. To assess the clinical outcomes of topical treatment of EMPD and establish the treatment guidelines the medical records of 166 patients diagnosed with EMPD were retrospectively reviewed. The recurrence rate was evaluated according to the previous use of topical agents. Thirty-four patients (34/166, 20.5%) were initially treated with topical agents such as imiquimod, 5-fluorouracil, and ingenol mebutate. Three patients (3/34, 8.8%) showed clinical response, while 31 patients required subsequent therapy owing to treatment failure. Analysis of the prognostic factors of recurrence in 166 patients revealed that initial topical treatment increased the hazard ratio (HR) in both univariate and multiple Cox proportional hazards models (HR = 3.770, 95% confidence interval [CI] = 1.768–8.037, P = 0.001, and adjusted HR = 3.628, 95% CI = 1.558–8.450, P = 0.003). Patients treated with topical agents showed significantly poorer 3-year recurrence-free survival than the nontreated group (66.3% vs 88.6%, P < 0.001). Topical treatment may be deleterious for some EMPD patients, thus increasing the recurrence risk.

Original languageEnglish
Pages (from-to)585-591
Number of pages7
JournalJournal of Dermatology
Issue number5
Publication statusPublished - 2021 May

Bibliographical note

Funding Information:
This study was supported by a faculty research grant of Yonsei University College of Medicine (6‐2020‐0102).

Publisher Copyright:
© 2021 Japanese Dermatological Association

All Science Journal Classification (ASJC) codes

  • Dermatology


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