Initial study on in vivo conductivity mapping of breast cancer using MRI

Jaewook Shin, Min Jung Kim, Joonsung Lee, Yoonho Nam, Min Oh Kim, Narae Choi, Sooyeon Kim, Dong Hyun Kim

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)


Purpose To develop and apply a method to measure in vivo electrical conductivity values using magnetic resonance imaging (MRI) in subjects with breast cancer. Materials and Methods A recently developed technique named MREPT (MR electrical properties tomography) together with a novel coil combination process was used to quantify the conductivity values. The overall technique was validated using a phantom study. In addition, 90 subjects were imaged (50 subjects with previously biopsy-confirmed breast tumor and 40 normal subjects), which was approved by our institutional review board (IRB). A routine clinical protocol, specifically a T2-weighted FSE (fast spin echo) imaging data, was used for reconstruction of conductivity. Results By employing the coil combination, the relative error in the conductivity map was reduced from ∼70% to 10%. The average conductivity values in breast cancers regions (0.89-±-0.33S/m) was higher compared to parenchymal tissue (0.43 S/m, P < 0.0001) and fat (0.07 S/m, P < 0.00005) regions. Malignant cases (0.89 S/m, n = 30) showed increased conductivity compared to benign cases (0.56 S/m, n = 5) (P < 0.05). In addition, invasive cancers (0.96 S/m) showed higher mean conductivity compared to in situ cancers (0.57 S/m) (P < 0.0005). Conclusion This study shows that conductivity mapping of breast cancers is feasible using a noninvasive in vivo MREPT technique combined with a coil combination process. The method may provide a tool in the MR diagnosis of breast cancer.

Original languageEnglish
Pages (from-to)371-378
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Issue number2
Publication statusPublished - 2015 Aug 1

Bibliographical note

Publisher Copyright:
© 2014 Wiley Periodicals, Inc.

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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