Inhibitory effects of plant extracts on tyrosinase activity and melanin synthesis

Hyen Joo Park, Kwang Kyun Park, Jae Kwan Hwang, Won Yoon Chung, Seung Eun Lee, Sang Kook Lee

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1 Citation (Scopus)


In order to develop a new skin whitening agent, approximately 100 plant extracts were evaluated for their inhibitory activities against melanin biosynthesis in cultured mouse melanocyte melan-a cells. As a result, seven extracts exhibited over 50% inhibition of melanin synthesis compared to control at a concentration of 20 μg/ml. In particular, Aster ageratoides Turcz. van ageratoides (branch, root, aerial, flower; IC50 = 17.3, 6.1, 13.6, 12.9 μg/ml, respectively) and Physalis alkekengi var. francheti (leaf, unripen fructus, aerial; IC50 = 6.5, 28.3, 23.9 μg/ml) markedly inhibited melanin synthesis. In addition, tyrosinase activity was monitored by the measurement of dopachrome formation from the oxidation of L-3,4-dihydroxyphenylalanine. Extracts of A. ageratoides Turcz. var. ageratoides (flower) and P. alkekengi var. francheti (leaf) showed the most potent tyrosinase inhibitory activity. These plants might be the potential candidate sources in the development of novel skin-whitening products.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalNatural Product Sciences
Issue number2
Publication statusPublished - 2010 Jun

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Organic Chemistry


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