Inhibitory effect of yellow myrobalan (Terminalia chebula) extract on fibrosis induced by carbon tetrachloride in rat liver

Yun Chang Koo, Chung Oui Hong, Mi Hyun Nam, Ji Hoon Kim, Sung Yong Yang, Nam Hee Won, Tae Sun Park, Kwang Won Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Ethyl acetate layer of methanol extract (TCE) of yellow myrobalan (Terminalia chebula) contains 2.4% of chebulic acid, a standard compound in TCE, which have a strong anti-oxidative effect and was reported in our previous study. Thirty-one male SD rats were randomly divided into 5 groups (normal control, CCl4 control, TCE control, CCl4+high dose TCE, and low dose TCE). Liver fibrosis was induced by i.p. injection of CCl4 and TCE were orally administrated. TCE decreased the up-regulated malondealdehyde value and increased the down-regulated ratio of GSH/GSSG content and activities of GRd, GPx, and GST compared to the CCl4 control group. Decreased dysfunction and inflammatory reaction in liver was confirmed by alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, relative liver weight and infiltration of neutrophils. Also, TCE inhibited phenotype change of hepatic stellate cells (HSC) by reducing α-smooth muscle actin (α-SMA) gene expression and protein production. Inhibition of collagen 1A1 gene expression and protein production were also confirmed. From these results, TCE may be a useful material for preventing liver fibrosis.

Original languageEnglish
Pages (from-to)871-880
Number of pages10
JournalFood Science and Biotechnology
Issue number3
Publication statusPublished - 2013 Jun

Bibliographical note

Funding Information:
Acknowledgments This research was supported by a Korea University Grant. The authors thank the Korea University-CJ Food Safety Center for providing the equipment and facilities.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology


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