Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus

Sung Keun Jung; Tae Gyu Lim; Jong Eun Kim; Sanguine Byun; Gye Won Kim; Jung Nam Choi; Choong Hwan Lee; Bo Yeon Kim; Ki Won Lee; Hyong Joo Lee

doi:10.1016/j.foodchem.2011.08.010

Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus

Sung Keun Jung, Tae Gyu Lim, Jong Eun Kim, Sanguine Byun, Gye Won Kim, Jung Nam Choi, Choong Hwan Lee, Bo Yeon Kim, Ki Won Lee, Hyong Joo Lee

Division of Life Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Consumption of fruits and vegetables is correlated with a lower incidence of cancer. Here, we identified hyperoside as an active compound from Acanthopanax sessiliflorus, and investigated the effect of hyperoside on UVB-induced transactivation of activator protein 1 (AP-1) and on the mitogen-activated protein kinase signalling pathway in JB6 P + cells. Hyperoside inhibited UVB-induced AP-1 transactivation. It inhibited the UVB-induced phosphorylation of p90^RSK. Kinase assays revealed that hyperoside significantly inhibited ERK1/2 activity. Furthermore, hyperoside bound to ERK1/2 to suppress its activity. In addition, phosphorylation of cAMP response element binding protein (CREB) and signal transducers and activators of transcription (STAT) 3 were suppressed by hyperoside. Overall, these results indicate that hyperoside may be a promising chemopreventive agent that acts by suppressing the transactivation of AP-1 and the phosphorylation of p90^RSK, CREB, and STAT3 through the binding and inhibition of ERK1/2.

Original language	English
Pages (from-to)	915-920
Number of pages	6
Journal	Food Chemistry
Volume	130
Issue number	4
DOIs	https://doi.org/10.1016/j.foodchem.2011.08.010
Publication status	Published - 2012 Feb 15

Bibliographical note

Funding Information:
This work was supported by grants from World Class University Program ( R31-2008-00-10056-0 ), World Class Institute Program ( 2009-002 ), Leap Research Program ( 2010-0029233 ), National Research Foundation of Korea Grant ( NRF-2009-352-F00043 ), and Technology Development Program for Agriculture and Forestry ( 107055-2 ), Republic of Korea .

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Food Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.foodchem.2011.08.010

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title = "Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus",

abstract = "Consumption of fruits and vegetables is correlated with a lower incidence of cancer. Here, we identified hyperoside as an active compound from Acanthopanax sessiliflorus, and investigated the effect of hyperoside on UVB-induced transactivation of activator protein 1 (AP-1) and on the mitogen-activated protein kinase signalling pathway in JB6 P + cells. Hyperoside inhibited UVB-induced AP-1 transactivation. It inhibited the UVB-induced phosphorylation of p90RSK. Kinase assays revealed that hyperoside significantly inhibited ERK1/2 activity. Furthermore, hyperoside bound to ERK1/2 to suppress its activity. In addition, phosphorylation of cAMP response element binding protein (CREB) and signal transducers and activators of transcription (STAT) 3 were suppressed by hyperoside. Overall, these results indicate that hyperoside may be a promising chemopreventive agent that acts by suppressing the transactivation of AP-1 and the phosphorylation of p90RSK, CREB, and STAT3 through the binding and inhibition of ERK1/2.",

author = "Jung, {Sung Keun} and Lim, {Tae Gyu} and Kim, {Jong Eun} and Sanguine Byun and Kim, {Gye Won} and Choi, {Jung Nam} and Lee, {Choong Hwan} and Kim, {Bo Yeon} and Lee, {Ki Won} and Lee, {Hyong Joo}",

note = "Funding Information: This work was supported by grants from World Class University Program ( R31-2008-00-10056-0 ), World Class Institute Program ( 2009-002 ), Leap Research Program ( 2010-0029233 ), National Research Foundation of Korea Grant ( NRF-2009-352-F00043 ), and Technology Development Program for Agriculture and Forestry ( 107055-2 ), Republic of Korea .",

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AU - Jung, Sung Keun

AU - Lim, Tae Gyu

AU - Kim, Jong Eun

AU - Byun, Sanguine

AU - Kim, Gye Won

AU - Choi, Jung Nam

AU - Lee, Choong Hwan

AU - Kim, Bo Yeon

AU - Lee, Ki Won

AU - Lee, Hyong Joo

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PY - 2012/2/15

Y1 - 2012/2/15

N2 - Consumption of fruits and vegetables is correlated with a lower incidence of cancer. Here, we identified hyperoside as an active compound from Acanthopanax sessiliflorus, and investigated the effect of hyperoside on UVB-induced transactivation of activator protein 1 (AP-1) and on the mitogen-activated protein kinase signalling pathway in JB6 P + cells. Hyperoside inhibited UVB-induced AP-1 transactivation. It inhibited the UVB-induced phosphorylation of p90RSK. Kinase assays revealed that hyperoside significantly inhibited ERK1/2 activity. Furthermore, hyperoside bound to ERK1/2 to suppress its activity. In addition, phosphorylation of cAMP response element binding protein (CREB) and signal transducers and activators of transcription (STAT) 3 were suppressed by hyperoside. Overall, these results indicate that hyperoside may be a promising chemopreventive agent that acts by suppressing the transactivation of AP-1 and the phosphorylation of p90RSK, CREB, and STAT3 through the binding and inhibition of ERK1/2.

AB - Consumption of fruits and vegetables is correlated with a lower incidence of cancer. Here, we identified hyperoside as an active compound from Acanthopanax sessiliflorus, and investigated the effect of hyperoside on UVB-induced transactivation of activator protein 1 (AP-1) and on the mitogen-activated protein kinase signalling pathway in JB6 P + cells. Hyperoside inhibited UVB-induced AP-1 transactivation. It inhibited the UVB-induced phosphorylation of p90RSK. Kinase assays revealed that hyperoside significantly inhibited ERK1/2 activity. Furthermore, hyperoside bound to ERK1/2 to suppress its activity. In addition, phosphorylation of cAMP response element binding protein (CREB) and signal transducers and activators of transcription (STAT) 3 were suppressed by hyperoside. Overall, these results indicate that hyperoside may be a promising chemopreventive agent that acts by suppressing the transactivation of AP-1 and the phosphorylation of p90RSK, CREB, and STAT3 through the binding and inhibition of ERK1/2.

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Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus

Abstract

Bibliographical note

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