Inhibitory constituents of Euonymus alatus leaves and twigs on nitric oxide production in BV2 microglia cells

Eun Ju Jeong; Heejung Yang; Seung Hyun Kim; So Young Kang; Sang Hyun Sung; Young Choong Kim

doi:10.1016/j.fct.2011.03.028

Inhibitory constituents of Euonymus alatus leaves and twigs on nitric oxide production in BV2 microglia cells

Eun Ju Jeong, Heejung Yang, Seung Hyun Kim, So Young Kang, Sang Hyun Sung, Young Choong Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The excessive and prolonged nitric oxide (NO) production has been linked to various inflammatory diseases as well as tumourigenesis. On the search for anti-inflammatory and anti-cancer compounds from the medicinal plants, the methanolic extract of Euonymus alatus (Thunb.) Sieb. (Celastraceae) was found to have significant inhibitory activity on NO production in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. Hence, we attempted to isolate the inhibitory constituent of E. alatus leaves and twigs on NO production. Thirteen compounds including two new glycerol derivates (1, 2), two C₁₃ isoprenoids (3, 4), two phenolics (5, 6) and seven flavonoids (7-13) were isolated, and the structures of 1-13 were elucidated by extensive 1D and 2D spectroscopic methods. The isolated compounds significantly inhibited NO production induced by LPS in BV2 microglia cells.

Original language	English
Pages (from-to)	1394-1398
Number of pages	5
Journal	Food and Chemical Toxicology
Volume	49
Issue number	6
DOIs	https://doi.org/10.1016/j.fct.2011.03.028
Publication status	Published - 2011 Jun

Bibliographical note

Funding Information:
This research was supported by a grant ( 2009K001285 ) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Education, Science and Technology, the Republic of Korea .

All Science Journal Classification (ASJC) codes

Food Science
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.fct.2011.03.028

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title = "Inhibitory constituents of Euonymus alatus leaves and twigs on nitric oxide production in BV2 microglia cells",

abstract = "The excessive and prolonged nitric oxide (NO) production has been linked to various inflammatory diseases as well as tumourigenesis. On the search for anti-inflammatory and anti-cancer compounds from the medicinal plants, the methanolic extract of Euonymus alatus (Thunb.) Sieb. (Celastraceae) was found to have significant inhibitory activity on NO production in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. Hence, we attempted to isolate the inhibitory constituent of E. alatus leaves and twigs on NO production. Thirteen compounds including two new glycerol derivates (1, 2), two C13 isoprenoids (3, 4), two phenolics (5, 6) and seven flavonoids (7-13) were isolated, and the structures of 1-13 were elucidated by extensive 1D and 2D spectroscopic methods. The isolated compounds significantly inhibited NO production induced by LPS in BV2 microglia cells.",

author = "Jeong, {Eun Ju} and Heejung Yang and Kim, {Seung Hyun} and Kang, {So Young} and Sung, {Sang Hyun} and Kim, {Young Choong}",

note = "Funding Information: This research was supported by a grant ( 2009K001285 ) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Education, Science and Technology, the Republic of Korea .",

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AU - Jeong, Eun Ju

AU - Yang, Heejung

AU - Kim, Seung Hyun

AU - Kang, So Young

AU - Sung, Sang Hyun

AU - Kim, Young Choong

N1 - Funding Information: This research was supported by a grant ( 2009K001285 ) from Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Education, Science and Technology, the Republic of Korea .

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Inhibitory constituents of Euonymus alatus leaves and twigs on nitric oxide production in BV2 microglia cells

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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