Inhibitors of osteoclastogenesis from Lawsonia inermis leaves

Nguyen Xuan Cuong, Nguyen Xuan Nhiem, Nguyen Phuong Thao, Nguyen Hoai Nam, Nguyen Tien Dat, Hoang Le Tuan Anh, Le Mai Huong, Phan Van Kiem, Chau Van Minh, Ji Hee Won, Won Yoon Chung, Young Ho Kim

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Ten phenolic compounds (1-10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-κB ligand-induced osteoclast formation in murine bone-marrow macrophages.

Original languageEnglish
Pages (from-to)4782-4784
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number16
Publication statusPublished - 2010 Aug 15

Bibliographical note

Funding Information:
This work was supported by VAST and partly by Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093815), Republic of Korea. The authors are grateful to Institute of Chemistry, VAST and KBSI for provision of spectroscopic instrument.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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