Inhibitors of osteoclastogenesis from Lawsonia inermis leaves

Nguyen Xuan Cuong; Nguyen Xuan Nhiem; Nguyen Phuong Thao; Nguyen Hoai Nam; Nguyen Tien Dat; Hoang Le Tuan Anh; Le Mai Huong; Phan Van Kiem; Chau Van Minh; Ji Hee Won; Won Yoon Chung; Young Ho Kim

doi:10.1016/j.bmcl.2010.06.118

Inhibitors of osteoclastogenesis from Lawsonia inermis leaves

Nguyen Xuan Cuong, Nguyen Xuan Nhiem, Nguyen Phuong Thao, Nguyen Hoai Nam, Nguyen Tien Dat, Hoang Le Tuan Anh, Le Mai Huong, Phan Van Kiem, Chau Van Minh, Ji Hee Won, Won Yoon Chung, Young Ho Kim

Department of Oral Biology

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Ten phenolic compounds (1-10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-κB ligand-induced osteoclast formation in murine bone-marrow macrophages.

Original language	English
Pages (from-to)	4782-4784
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2010.06.118
Publication status	Published - 2010 Aug 15

Bibliographical note

Funding Information:
This work was supported by VAST and partly by Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093815), Republic of Korea. The authors are grateful to Institute of Chemistry, VAST and KBSI for provision of spectroscopic instrument.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2010.06.118

Cite this

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title = "Inhibitors of osteoclastogenesis from Lawsonia inermis leaves",

abstract = "Ten phenolic compounds (1-10) were isolated from a methanol extract of Lawsonia inermis leaves including two new ones, lawsoniasides A (1) and B (2). Their structures were elucidated by spectroscopic methods (NMR and FTICRMS) in combination with acid hydrolysis and GC analyses. Compounds 4 and 5 showed a significant inhibition on receptor activator for nuclear factor-κB ligand-induced osteoclast formation in murine bone-marrow macrophages.",

author = "Cuong, {Nguyen Xuan} and Nhiem, {Nguyen Xuan} and Thao, {Nguyen Phuong} and Nam, {Nguyen Hoai} and Dat, {Nguyen Tien} and Anh, {Hoang Le Tuan} and Huong, {Le Mai} and Kiem, {Phan Van} and Minh, {Chau Van} and Won, {Ji Hee} and Chung, {Won Yoon} and Kim, {Young Ho}",

note = "Funding Information: This work was supported by VAST and partly by Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093815), Republic of Korea. The authors are grateful to Institute of Chemistry, VAST and KBSI for provision of spectroscopic instrument. ",

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doi = "10.1016/j.bmcl.2010.06.118",

language = "English",

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AU - Cuong, Nguyen Xuan

AU - Nhiem, Nguyen Xuan

AU - Thao, Nguyen Phuong

AU - Nam, Nguyen Hoai

AU - Dat, Nguyen Tien

AU - Anh, Hoang Le Tuan

AU - Huong, Le Mai

AU - Kiem, Phan Van

AU - Minh, Chau Van

AU - Won, Ji Hee

AU - Chung, Won Yoon

AU - Kim, Young Ho

N1 - Funding Information: This work was supported by VAST and partly by Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009-0093815), Republic of Korea. The authors are grateful to Institute of Chemistry, VAST and KBSI for provision of spectroscopic instrument.

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Y1 - 2010/8/15

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Inhibitors of osteoclastogenesis from Lawsonia inermis leaves

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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