Inhibition of neointimal proliferation of rat carotid artery by sulodexide

Hyun Young Park, Seokmin Kang, Geon Young Kim, Yangsoo Jang, Hyuck Moon Kwon, Won Heum Shim, Seung Yeon Cho, Sang Ho Cho

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12 Citations (Scopus)


Sulodexide, a glycosaminoglycan-containing compound, is known to have an antiproliferative effect on vascular smooth-muscle cells, in vitro, as well as antithrombotic and fibrinolytic effects. But there are few reports about the effect on neointimal proliferation in vivo. In this study, we examined whether Sulodexide was effective in the inhibition of neointimal proliferation after vascular injury. Ten-week-old Sprague-Dawley rats were subjected to vascular injury by endothelial denudation of the common carotid artery by using a balloon catheter. They were then allocated randomly into a control group (saline 2 ml for 3 days, and then 1 ml for 18 days, IM) and a treated group (Sulodexide 10 mg/kg/day for 3 days, and then 4 mg/kg/day for 18 days, IM). Three weeks after vascular injury, we analyzed the neointimal proliferation using morphometry. The neointimal proliferation was significantly reduced in the treated group compared to the control group (Ratio of neointimal area to medial area; 118.39±6.80% in the treated group, 177.25±17.25% in the control group). This result showed that Sulodexide might be effective in reducing the rate of restenosis after balloon angioplasty.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalJournal of Korean medical science
Issue number3
Publication statusPublished - 1997

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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