Inhibition of developmental processes by flavone in Caenorhabditis elegans and its application to the pinewood nematode,Bursaphelenchus xylophilus

Flavone (2-phenyl chromone) is a well-known plant flavonoid, but its bioactivity has been little explored. Treatment of Caernohabditis elegans. or C. brissage with flavones induced embryonic and larval lethality that was pronounced in early larval stages. This anti-nematodal effect was also observed in the pinewood nematode, B. xylophilus LD₅₀ values were approximately 100 M for both B. xylophilus and C. elegans. Our results indicate that flavone is an active nematicidal compound that should be further investigated with the aim of developing a potent drug against B. xylophilus.