Inhibited apoptosis of C2C12 myoblasts by a eupatorium chinense var. simplicifolium root extract

Jin Ho Lee; Min Ho Jung; Yong Hyeon Lee; Yusu Shin; Han Sung Kim; Jürgen Schreiber; Tack Joong Kim

doi:10.1271/bbb.130333

Inhibited apoptosis of C₂C₁₂ myoblasts by a eupatorium chinense var. simplicifolium root extract

Jin Ho Lee, Min Ho Jung, Yong Hyeon Lee, Yusu Shin, Han Sung Kim, Jürgen Schreiber, Tack Joong Kim

Division of Medical Engineering

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We investigated the effects of a Eupatorium chinense var. simplicifolium (EUC) root extract on muscle disorders and explored the underlying mechanism for oxidative stress-induced C₂C₁₂ myoblast damage. An EUC pre-treatment reduced the decreased cell viability after an H₂O ₂ treatment. The heat shock protein (HSP) 70 level increased, and the phosphorylation of Jun amino-terminal kinases (JNKs) decreased in the EUCpre- treated C₂C₁₂ myoblasts. The results of the present study demonstrate the potential benefit of a herbal medicine in treating oxidative stress-related muscle disorders.

Original language	English
Pages (from-to)	2134-2136
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	77
Issue number	10
DOIs	https://doi.org/10.1271/bbb.130333
Publication status	Published - 2013

Bibliographical note

Funding Information:
This research was supported by the Leading Space Core Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2011-00300888), and This research was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2010-00757).

All Science Journal Classification (ASJC) codes

Medicine(all)

Access to Document

10.1271/bbb.130333

Cite this

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title = "Inhibited apoptosis of C2C12 myoblasts by a eupatorium chinense var. simplicifolium root extract",

abstract = "We investigated the effects of a Eupatorium chinense var. simplicifolium (EUC) root extract on muscle disorders and explored the underlying mechanism for oxidative stress-induced C2C12 myoblast damage. An EUC pre-treatment reduced the decreased cell viability after an H2O 2 treatment. The heat shock protein (HSP) 70 level increased, and the phosphorylation of Jun amino-terminal kinases (JNKs) decreased in the EUCpre- treated C2C12 myoblasts. The results of the present study demonstrate the potential benefit of a herbal medicine in treating oxidative stress-related muscle disorders.",

author = "Lee, {Jin Ho} and Jung, {Min Ho} and Lee, {Yong Hyeon} and Yusu Shin and Kim, {Han Sung} and J{\"u}rgen Schreiber and Kim, {Tack Joong}",

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AU - Lee, Jin Ho

AU - Jung, Min Ho

AU - Lee, Yong Hyeon

AU - Shin, Yusu

AU - Kim, Han Sung

AU - Schreiber, Jürgen

AU - Kim, Tack Joong

N1 - Funding Information: This research was supported by the Leading Space Core Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2011-00300888), and This research was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2010-00757).

PY - 2013

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