Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease:A Retrospective Cohort Study

Jae Hak Kim; Jae Hee Cheon; Seong Soo Hong; Chang Soo Eun; Jeong Sik Byeon; Sung Yi Hong; Bo Young Kim; Soon ho Kwon; Seung Won Kim; Dong Soo Han; Suk Kyun Yang; Won Ho Kim

doi:10.1097/MCG.0b013e3181d6baf5

Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease:A Retrospective Cohort Study

Jae Hak Kim, Jae Hee Cheon, Seong Soo Hong, Chang Soo Eun, Jeong Sik Byeon, Sung Yi Hong, Bo Young Kim, Soon ho Kwon, Seung Won Kim, Dong Soo Han, Suk Kyun Yang, Won Ho Kim

Department of Internal Medicine

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83 Citations (Scopus)

Abstract

Myelotoxicity has been shown to be very common in Korean patients with inflammatory bowel disease (IBD) during azathioprine (AZA) or 6-mercaptopurine (6-MP) treatment. The purpose of this study was to investigate the relative risk of the thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genotypes and TPMT activity for the development of leukopenia in Korean IBD patients during AZA/6-MP treatment.

Original language	English
Pages (from-to)	e242-e248
Journal	Journal of Clinical Gastroenterology
Volume	44
Issue number	10
DOIs	https://doi.org/10.1097/MCG.0b013e3181d6baf5
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

Gastroenterology

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10.1097/MCG.0b013e3181d6baf5

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Kim, J. H., Cheon, J. H., Hong, S. S., Eun, C. S., Byeon, J. S., Hong, S. Y., Kim, B. Y., Kwon, S. H., Kim, S. W., Han, D. S., Yang, S. K., & Kim, W. H. (2010). Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease:A Retrospective Cohort Study. Journal of Clinical Gastroenterology, 44(10), e242-e248. https://doi.org/10.1097/MCG.0b013e3181d6baf5

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title = "Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease:A Retrospective Cohort Study",

abstract = "Myelotoxicity has been shown to be very common in Korean patients with inflammatory bowel disease (IBD) during azathioprine (AZA) or 6-mercaptopurine (6-MP) treatment. The purpose of this study was to investigate the relative risk of the thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genotypes and TPMT activity for the development of leukopenia in Korean IBD patients during AZA/6-MP treatment.",

author = "Kim, {Jae Hak} and Cheon, {Jae Hee} and Hong, {Seong Soo} and Eun, {Chang Soo} and Byeon, {Jeong Sik} and Hong, {Sung Yi} and Kim, {Bo Young} and Kwon, {Soon ho} and Kim, {Seung Won} and Han, {Dong Soo} and Yang, {Suk Kyun} and Kim, {Won Ho}",

year = "2010",

doi = "10.1097/MCG.0b013e3181d6baf5",

language = "English",

volume = "44",

pages = "e242--e248",

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Kim, JH, Cheon, JH, Hong, SS, Eun, CS, Byeon, JS, Hong, SY, Kim, BY, Kwon, SH, Kim, SW, Han, DS, Yang, SK & Kim, WH 2010, 'Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease:A Retrospective Cohort Study', Journal of Clinical Gastroenterology, vol. 44, no. 10, pp. e242-e248. https://doi.org/10.1097/MCG.0b013e3181d6baf5

Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease:A Retrospective Cohort Study. / Kim, Jae Hak; Cheon, Jae Hee; Hong, Seong Soo et al.
In: Journal of Clinical Gastroenterology, Vol. 44, No. 10, 2010, p. e242-e248.

Research output: Contribution to journal › Article › peer-review

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AU - Kim, Jae Hak

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AU - Hong, Seong Soo

AU - Eun, Chang Soo

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AU - Kim, Bo Young

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AU - Kim, Seung Won

AU - Han, Dong Soo

AU - Yang, Suk Kyun

AU - Kim, Won Ho

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AB - Myelotoxicity has been shown to be very common in Korean patients with inflammatory bowel disease (IBD) during azathioprine (AZA) or 6-mercaptopurine (6-MP) treatment. The purpose of this study was to investigate the relative risk of the thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genotypes and TPMT activity for the development of leukopenia in Korean IBD patients during AZA/6-MP treatment.

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Influences of Thiopurine Methyltransferase Genotype and Activity on Thiopurine-induced Leukopenia in Korean Patients With Inflammatory Bowel Disease:A Retrospective Cohort Study

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