Influence of water soluble additives and HPMCP on drug release from surelease®-coated pellets containing tamsulosin hydrochloride

Min Soo Kim; Jeong Soo Kim; Sun Ho Kang; Yeon Hee Yoo; Sibeum Lee; Jeong Sook Park; Jong Soo Woo; Sung Joo Hwang

doi:10.1007/BF02993970

Influence of water soluble additives and HPMCP on drug release from surelease®-coated pellets containing tamsulosin hydrochloride

Min Soo Kim, Jeong Soo Kim, Sun Ho Kang, Yeon Hee Yoo, Sibeum Lee, Jeong Sook Park, Jong Soo Woo, Sung Joo Hwang

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The objective of this study was to investigate the influence of various water-soluble additives and HPMCP as an enteric polymer into Surelease® for the developement of oral controlled release system containg tamsulosin hydrochloride. The drug loaded pellets were coated with only Surelease® or Surelease® containing HPMC, PEG 4000, mannitol and HPMCP (20% w/w). In case of HPMC and PEG 4000 as additives into Surelease® film, the rapid drug release was observed in pH 1.2 while the higher drug release was achieved by adding HPMCP into Surelease® as well as by increasing the amount of HPMCP (10, 20, and 30% w/w) in pH 7.2. The incorporation of HPMCP into Surelease® showed pH-denpendent drug release due to its pH-dependent nature. Therefore, the incorporation of HPMCP into Surelease® based on aqueous coating formulation is an effective way to develop oral controlled release delivery systems containing tamsulosin hydrochloride.

Original language	English
Pages (from-to)	1008-1013
Number of pages	6
Journal	Archives of pharmacal research
Volume	30
Issue number	8
DOIs	https://doi.org/10.1007/BF02993970
Publication status	Published - 2007 Aug 31

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the National Research Lab. Program funded by the Ministry of Science and Technology (No. M10300000301-06J0000-30110).

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery
Organic Chemistry

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title = "Influence of water soluble additives and HPMCP on drug release from surelease{\textregistered}-coated pellets containing tamsulosin hydrochloride",

abstract = "The objective of this study was to investigate the influence of various water-soluble additives and HPMCP as an enteric polymer into Surelease{\textregistered} for the developement of oral controlled release system containg tamsulosin hydrochloride. The drug loaded pellets were coated with only Surelease{\textregistered} or Surelease{\textregistered} containing HPMC, PEG 4000, mannitol and HPMCP (20% w/w). In case of HPMC and PEG 4000 as additives into Surelease{\textregistered} film, the rapid drug release was observed in pH 1.2 while the higher drug release was achieved by adding HPMCP into Surelease{\textregistered} as well as by increasing the amount of HPMCP (10, 20, and 30% w/w) in pH 7.2. The incorporation of HPMCP into Surelease{\textregistered} showed pH-denpendent drug release due to its pH-dependent nature. Therefore, the incorporation of HPMCP into Surelease{\textregistered} based on aqueous coating formulation is an effective way to develop oral controlled release delivery systems containing tamsulosin hydrochloride.",

author = "Kim, {Min Soo} and Kim, {Jeong Soo} and Kang, {Sun Ho} and Yoo, {Yeon Hee} and Sibeum Lee and Park, {Jeong Sook} and Woo, {Jong Soo} and Hwang, {Sung Joo}",

note = "Funding Information: This work was supported by the Korea Science and Engineering Foundation (KOSEF) through the National Research Lab. Program funded by the Ministry of Science and Technology (No. M10300000301-06J0000-30110).",

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AU - Lee, Sibeum

AU - Park, Jeong Sook

AU - Woo, Jong Soo

AU - Hwang, Sung Joo

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N2 - The objective of this study was to investigate the influence of various water-soluble additives and HPMCP as an enteric polymer into Surelease® for the developement of oral controlled release system containg tamsulosin hydrochloride. The drug loaded pellets were coated with only Surelease® or Surelease® containing HPMC, PEG 4000, mannitol and HPMCP (20% w/w). In case of HPMC and PEG 4000 as additives into Surelease® film, the rapid drug release was observed in pH 1.2 while the higher drug release was achieved by adding HPMCP into Surelease® as well as by increasing the amount of HPMCP (10, 20, and 30% w/w) in pH 7.2. The incorporation of HPMCP into Surelease® showed pH-denpendent drug release due to its pH-dependent nature. Therefore, the incorporation of HPMCP into Surelease® based on aqueous coating formulation is an effective way to develop oral controlled release delivery systems containing tamsulosin hydrochloride.

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Influence of water soluble additives and HPMCP on drug release from surelease®-coated pellets containing tamsulosin hydrochloride

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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