Influence of the IL-6 -572C > G polymorphism on inflammatory markers according to cigarette smoking in Korean healthy men

Kyung Kyun Shin, Yangsoo Jang, Soo Jeong Koh, Jey Sook Chae, Oh Yoen Kim, Sungha Park, Donghoon Choi, Dong Jik Shin, Hyae Jin Kim, Jong Ho Lee

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15 Citations (Scopus)


We investigated whether smoking would interact with the interleukin-6 (IL-6) polymorphisms (-174G > C and -572C > G, -597G > A and -1363G > T) in determining circulating levels of inflammatory markers and its consequence to oxidative stress. The G/G genotype (n = 26) of the -572C > G in nonsmokers (n = 376) was associated with higher IL-6 (P = 0.028), fibrinogen (P = 0.007) and ox-LDL (P = 0.006) than those with C/C (n = 209) or C/G (n = 141). Results were similar for nonsmokers and smokers (n = 268), but in smokers, the -572G/G genotype was associated with a greater difference in levels of IL-6 (P = 0.031), fibrinogen (P = 0.001), ox-LDL (P = 0.037) and PGF (P = 0.050). IL-6 had positive relations with CRP, fibrinogen, ox-LDL and PGF. There was no evidence of an effect of -572C > G genotype on CRP levels in nonsmokers, however, this polymorphism was associated with a highly significant effect on CRP in smokers (P < 0.001) (genotype-smoking interaction P = 0.04, adjusted for age, BMI and IL-6). The C allele frequency at the -174 promoter region of IL-6 was very rare (<0.01) and -597G > A and -1363G > T were monomorphic in this study. Our results suggest that IL-6 -572C > G has a greater response over time to the inflammatory effects of smoking and this may result in smokers having higher oxidative stress in subjects with G/G compared to C/C or C/G.

Original languageEnglish
Pages (from-to)116-122
Number of pages7
Issue number2
Publication statusPublished - 2007 Aug

Bibliographical note

Funding Information:
Healthy male subjects (n = 644) were recruited concomitantly from participants in prospective human genetic study, supported by a Genome Research Development Project on Health and Medicine (Project No. A000385), Ministry of Health and Welfare. The inclusion criteria were 38 ⩽ age 3 cigarettes per day as ‘regular smokers’ (n = 268).

Funding Information:
This study was partly supported by (1) Ministry of Science and Technology, Seoul, Korea (M10642120002-06N4212-00210); (2) National Research Laboratory Project No. R0A-2005-000-10144-0, Ministry of Science and Technology, Seoul, Korea; (3) Korea Health 21 R&D Projects, Ministry of Health and Welfare, Seoul, Korea (A000385, A050376).

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology


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