Independent association of TG/HDL-C with urinary albumin excretion in normotensive subjects in a rural Korean population

Hee Taik Kang, Jong Koo Kim, Jang Young Kim, John A. Linton, Jin Ha Yoon, Sang Baek Koh

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25 Citations (Scopus)


Background: The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases in some ethnic groups. This study is performed to examine the association between TG/HDL-C and albuminuria. Methods: This cross-sectional study included 9094 adult subjects (4091 men, 5003 women) who were enrolled in the Korean Genomic Rural Cohort (KGRC) and aged 40. years or more. Albuminuria was defined as a urine albumin/creatinine ratio ≥ 30 mg/g. Participants were categorized into TG/HDL-C quartile. Results: Compared to the lowest TG/HDL-C quartile (< 1.94 in men, < 1.71 in women), the odds ratios (ORs) for albuminuria in participants who were categorized in the highest TG/HDL-C quartile (≥ 4.98 in men, ≥ 4.20 in women) were 1.30 (95% CI: 0.97-1.75) and 1.36 (1.03-1.79) in men and women, respectively, when adjusted for blood pressure and other covariates. In normotensive men and women, the ORs for albuminuria in the highest TG/HDL-C quartile were 1.58 (1.04-2.39) and 1.68 (1.15-2.45), respectively, even after fully adjusted. In contrast, TG/HDL-C was not associated with albuminuria in hypertensive subjects. Conclusions: TG/HDL-C was independently associated with increased prevalence of albuminuria in normotensive rural Korean subjects aged 40. years or more in KGRC.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalClinica Chimica Acta
Issue number1-2
Publication statusPublished - 2012 Jan 18

Bibliographical note

Funding Information:
We thank all team members of the Cohort study at Wonju Christian Hospital for their helpful discussion and comments. This study is supported in part by a grant from the Korean Centers for Disease Control and Prevention (Research Serial Number: 2005-E71013-00, 2006-E71002-00, and 2007-E71013-00 ).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical


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