TY - JOUR
T1 - Incremental prognostic value of coronary computed tomographic angiography over coronary artery calcium score for risk prediction of major adverse cardiac events in asymptomatic diabetic individuals
AU - Min, James K.
AU - Labounty, Troy M.
AU - Gomez, Millie J.
AU - Achenbach, Stephan
AU - Al-Mallah, Mouaz
AU - Budoff, Matthew J.
AU - Cademartiri, Filippo
AU - Callister, Tracy Q.
AU - Chang, Hyuk Jae
AU - Cheng, Victor
AU - Chinnaiyan, Kavitha M.
AU - Chow, Benjamin
AU - Cury, Ricardo
AU - Delago, Augustin
AU - Dunning, Allison
AU - Feuchtner, Gudrun
AU - Hadamitzky, Martin
AU - Hausleiter, Jorg
AU - Kaufmann, Philipp
AU - Kim, Yong Jin
AU - Leipsic, Jonathon
AU - Lin, Fay Y.
AU - Maffei, Erica
AU - Raff, Gilbert
AU - Shaw, Leslee J.
AU - Villines, Todd C.
AU - Berman, Daniel S.
PY - 2014/2
Y1 - 2014/2
N2 - Background: Coronary artery disease (CAD) diagnosis by coronary computed tomographic angiography (CCTA) is useful for identification of symptomatic diabetic individuals at heightened risk for death. Whether CCTA-detected CAD enables improved risk assessment of asymptomatic diabetic individuals beyond clinical risk factors and coronary artery calcium scoring (CACS) remains unexplored. Methods: From a prospective 12-center international registry of 27,125 individuals undergoing CCTA, we identified 400 asymptomatic diabetic individuals without known CAD. Coronary stenosis by CCTA was graded as 0%, 1-49%, 50-69%, and ≥70%. CAD was judged on a per-patient, per-vessel and per-segment basis as maximal stenosis severity, number of vessels with ≥50% stenosis, and coronary segments weighted for stenosis severity (segment stenosis score), respectively. We assessed major adverse cardiovascular events (MACE) - inclusive of mortality, nonfatal myocardial infarction (MI), and late target vessel revascularization ≥90 days (REV)- and evaluated the incremental utility of CCTA for risk prediction, discrimination and reclassification.
AB - Background: Coronary artery disease (CAD) diagnosis by coronary computed tomographic angiography (CCTA) is useful for identification of symptomatic diabetic individuals at heightened risk for death. Whether CCTA-detected CAD enables improved risk assessment of asymptomatic diabetic individuals beyond clinical risk factors and coronary artery calcium scoring (CACS) remains unexplored. Methods: From a prospective 12-center international registry of 27,125 individuals undergoing CCTA, we identified 400 asymptomatic diabetic individuals without known CAD. Coronary stenosis by CCTA was graded as 0%, 1-49%, 50-69%, and ≥70%. CAD was judged on a per-patient, per-vessel and per-segment basis as maximal stenosis severity, number of vessels with ≥50% stenosis, and coronary segments weighted for stenosis severity (segment stenosis score), respectively. We assessed major adverse cardiovascular events (MACE) - inclusive of mortality, nonfatal myocardial infarction (MI), and late target vessel revascularization ≥90 days (REV)- and evaluated the incremental utility of CCTA for risk prediction, discrimination and reclassification.
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U2 - 10.1016/j.atherosclerosis.2013.09.025
DO - 10.1016/j.atherosclerosis.2013.09.025
M3 - Article
C2 - 24468142
AN - SCOPUS:84892844703
SN - 0021-9150
VL - 232
SP - 298
EP - 304
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -
