Increased sphingosine kinase 1 expression predicts distant metastasis and poor outcome in patients with colorectal cancer

Go Eun Bae, Sung Im Do, Kyungeun Kim, Ji Hyun Park, Sihyun Cho, Hyun Soo Kim

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


Background/Aim: Sphingosine kinase 1 (SPHK1) is up-regulated in many different cancers and plays a crucial role in tumor development and progression. However, the prognostic value of SPHK1 in colorectal cancer (CRC) remains unclear. Materials and Methods: The expression of SPHK1 in CRC cell lines and 328 CRC tissue samples was examined. It was also investigated whether SPHK1 expression is associated with clinicopathological characteristics and outcomes in patients with CRC. Results: HCT 116 and HT-29 cells expressed significantly higher SPHK1 levels than did CCD 841 CoTr. On immunohistochemistry, SPHK1 expression was significantly higher in CRC tissue than in normal colonic mucosal tissue, with 34.1% of CRC patients exhibiting high SPHK1 expression. High SPHK1 expression in CRC was significantly associated with higher histological grade, deeper invasion depth, lymphatic invasion, vascular invasion, and development of distant metastasis, and was shown to be an independent predictor of distant metastasis. Furthermore, patients with high SPHK1 expression had significantly lower overall survival rates than those with low expression. Conclusion: High SPHK1 expression was significantly associated with aggressive CRC behavior and worse overall survival, and was an independent predictor of distant metastasis. SPHK1 may thus be a potential prognostic biomarker and therapeutic target in CRC patients.

Original languageEnglish
Pages (from-to)663-670
Number of pages8
JournalAnticancer research
Issue number2
Publication statusPublished - 2019 Feb

Bibliographical note

Funding Information:
This research was supported by a faculty research grant from Yonsei University College of Medicine (6-2018-0049) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2018R1C1B5043725).

Publisher Copyright:
© International Institute of Anticancer Research. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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