Increased serum interleukin-17 in Graves' ophthalmopathy

Sung Eun Kim; Jin Sook Yoon; Keun Ho Kim; Sang Yeul Lee

doi:10.1007/s00417-012-2092-7

Increased serum interleukin-17 in Graves' ophthalmopathy

Sung Eun Kim, Jin Sook Yoon, Keun Ho Kim, Sang Yeul Lee

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

Background Interleukin (IL)-17 and T helper 17 (Th17) cells are reported to be involved in many autoimmune diseases. The aim of this study is to investigate the involvement of IL-17 in the pathogenesis and disease activity of Graves' ophthalmopathy (GO). Methods Sixty-two GO patients and 19 healthy controls were recruited. Serum concentrations of cytokines, IL-17, IL-6, IL-23, and IL-16, were measured using multiplexed microsphere-based flow cytometric immunoassays. GO hormonal parameters, clinical activity score (CAS), exophthalmometry, and extraocular muscle involvement were evaluated, and relationships with cytokine concentrations were analyzed. Results The concentration and positive detection rates of serum IL-17 were significantly higher in patients with GO than in controls. The serum levels of IL-17 in active GO patients were higher than that of inactive GO patients. Serum IL-17 concentration had significant correlation with CAS (p<0.001). Conclusion The increased serum level of IL-17 and related cytokines in GO patients and the correlation of IL-17 concentration with the clinical activity scores suggest that IL-17 may play a pathophysiological role in GO.

Original language	English
Pages (from-to)	1521-1526
Number of pages	6
Journal	Graefe's Archive for Clinical and Experimental Ophthalmology
Volume	250
Issue number	10
DOIs	https://doi.org/10.1007/s00417-012-2092-7
Publication status	Published - 2012 Oct

Bibliographical note

Funding Information:
Acknowledgments Approval to conduct this study was obtained from the Institutional Review Board of the Yonsei University College of Medicine, Seoul, Korea. The study was conducted in accordance with the tenets of the Declaration of Helsinki, and written informed consent was obtained from all the study participants. This study was supported by a grant from the Yonsei University College of Medicine (grant number 6-2010-0180).

All Science Journal Classification (ASJC) codes

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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title = "Increased serum interleukin-17 in Graves' ophthalmopathy",

abstract = "Background Interleukin (IL)-17 and T helper 17 (Th17) cells are reported to be involved in many autoimmune diseases. The aim of this study is to investigate the involvement of IL-17 in the pathogenesis and disease activity of Graves' ophthalmopathy (GO). Methods Sixty-two GO patients and 19 healthy controls were recruited. Serum concentrations of cytokines, IL-17, IL-6, IL-23, and IL-16, were measured using multiplexed microsphere-based flow cytometric immunoassays. GO hormonal parameters, clinical activity score (CAS), exophthalmometry, and extraocular muscle involvement were evaluated, and relationships with cytokine concentrations were analyzed. Results The concentration and positive detection rates of serum IL-17 were significantly higher in patients with GO than in controls. The serum levels of IL-17 in active GO patients were higher than that of inactive GO patients. Serum IL-17 concentration had significant correlation with CAS (p<0.001). Conclusion The increased serum level of IL-17 and related cytokines in GO patients and the correlation of IL-17 concentration with the clinical activity scores suggest that IL-17 may play a pathophysiological role in GO.",

author = "Kim, {Sung Eun} and Yoon, {Jin Sook} and Kim, {Keun Ho} and Lee, {Sang Yeul}",

note = "Funding Information: Acknowledgments Approval to conduct this study was obtained from the Institutional Review Board of the Yonsei University College of Medicine, Seoul, Korea. The study was conducted in accordance with the tenets of the Declaration of Helsinki, and written informed consent was obtained from all the study participants. This study was supported by a grant from the Yonsei University College of Medicine (grant number 6-2010-0180).",

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AU - Lee, Sang Yeul

N1 - Funding Information: Acknowledgments Approval to conduct this study was obtained from the Institutional Review Board of the Yonsei University College of Medicine, Seoul, Korea. The study was conducted in accordance with the tenets of the Declaration of Helsinki, and written informed consent was obtained from all the study participants. This study was supported by a grant from the Yonsei University College of Medicine (grant number 6-2010-0180).

PY - 2012/10

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N2 - Background Interleukin (IL)-17 and T helper 17 (Th17) cells are reported to be involved in many autoimmune diseases. The aim of this study is to investigate the involvement of IL-17 in the pathogenesis and disease activity of Graves' ophthalmopathy (GO). Methods Sixty-two GO patients and 19 healthy controls were recruited. Serum concentrations of cytokines, IL-17, IL-6, IL-23, and IL-16, were measured using multiplexed microsphere-based flow cytometric immunoassays. GO hormonal parameters, clinical activity score (CAS), exophthalmometry, and extraocular muscle involvement were evaluated, and relationships with cytokine concentrations were analyzed. Results The concentration and positive detection rates of serum IL-17 were significantly higher in patients with GO than in controls. The serum levels of IL-17 in active GO patients were higher than that of inactive GO patients. Serum IL-17 concentration had significant correlation with CAS (p<0.001). Conclusion The increased serum level of IL-17 and related cytokines in GO patients and the correlation of IL-17 concentration with the clinical activity scores suggest that IL-17 may play a pathophysiological role in GO.

AB - Background Interleukin (IL)-17 and T helper 17 (Th17) cells are reported to be involved in many autoimmune diseases. The aim of this study is to investigate the involvement of IL-17 in the pathogenesis and disease activity of Graves' ophthalmopathy (GO). Methods Sixty-two GO patients and 19 healthy controls were recruited. Serum concentrations of cytokines, IL-17, IL-6, IL-23, and IL-16, were measured using multiplexed microsphere-based flow cytometric immunoassays. GO hormonal parameters, clinical activity score (CAS), exophthalmometry, and extraocular muscle involvement were evaluated, and relationships with cytokine concentrations were analyzed. Results The concentration and positive detection rates of serum IL-17 were significantly higher in patients with GO than in controls. The serum levels of IL-17 in active GO patients were higher than that of inactive GO patients. Serum IL-17 concentration had significant correlation with CAS (p<0.001). Conclusion The increased serum level of IL-17 and related cytokines in GO patients and the correlation of IL-17 concentration with the clinical activity scores suggest that IL-17 may play a pathophysiological role in GO.

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Increased serum interleukin-17 in Graves' ophthalmopathy

Abstract

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