Increased serum interleukin-17 in Graves' ophthalmopathy

Sung Eun Kim, Jin Sook Yoon, Keun Ho Kim, Sang Yeul Lee

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46 Citations (Scopus)


Background Interleukin (IL)-17 and T helper 17 (Th17) cells are reported to be involved in many autoimmune diseases. The aim of this study is to investigate the involvement of IL-17 in the pathogenesis and disease activity of Graves' ophthalmopathy (GO). Methods Sixty-two GO patients and 19 healthy controls were recruited. Serum concentrations of cytokines, IL-17, IL-6, IL-23, and IL-16, were measured using multiplexed microsphere-based flow cytometric immunoassays. GO hormonal parameters, clinical activity score (CAS), exophthalmometry, and extraocular muscle involvement were evaluated, and relationships with cytokine concentrations were analyzed. Results The concentration and positive detection rates of serum IL-17 were significantly higher in patients with GO than in controls. The serum levels of IL-17 in active GO patients were higher than that of inactive GO patients. Serum IL-17 concentration had significant correlation with CAS (p<0.001). Conclusion The increased serum level of IL-17 and related cytokines in GO patients and the correlation of IL-17 concentration with the clinical activity scores suggest that IL-17 may play a pathophysiological role in GO.

Original languageEnglish
Pages (from-to)1521-1526
Number of pages6
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number10
Publication statusPublished - 2012 Oct

Bibliographical note

Funding Information:
Acknowledgments Approval to conduct this study was obtained from the Institutional Review Board of the Yonsei University College of Medicine, Seoul, Korea. The study was conducted in accordance with the tenets of the Declaration of Helsinki, and written informed consent was obtained from all the study participants. This study was supported by a grant from the Yonsei University College of Medicine (grant number 6-2010-0180).

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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