Incorporation of carboxybetaine methacrylate into poly(methyl methacrylate) to prevent multi-species biofilm formation

Jie Jin, Ji Yeong Kim, Woojin Choi, Myung Jin Lee, Ji Young Seo, Jaehun Yu, Jae Sung Kwon, Jinkee Hong, Sung Hwan Choi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Carboxybetaine methacrylate (CBMA), which has anti-biofouling properties, was incorporated into poly(methyl methacrylate) (PMMA) to prevent multi-species biofilm formation without impairing the critical mechanical properties of the PMMA. The incorporation of 2-methacryloyloxyethyl phosphorylcholine (MPC, 3 wt%) was used as a positive control. PMMA wettability was found to increase with increasing CBMA content. The addition of CBMA resulted in decreased mechanical properties of PMMA. The incorporation of 3% CBMA into PMMA resulted in considerable long-term anti-biofouling effects that reduce adhesion of various fungi, bacteria (Candida albicans, Actinomyces naeslundii, and Veillonella parvula), and a human saliva-derived biofilm. The anti-biofouling effect of CBMA-incorporated PMMA surpassed that of the positive control. By calculating the intensity of the collective band using Raman spectroscopy, CBMA was proven to form the most stable hydration layer. Neither CBMA nor MPC groups showed cytotoxicity. Occlusal splints fabricated using 3% CBMA showed clinically acceptable aesthetic properties with slight turbidity. Despite a limitation in terms of deteriorations of the mechanical properties, the addition of an appropriate amount of CBMA to PMMA inhibited the attachment of fungi and bacteria and suppressed multi-species biofilm growth. The aesthetic properties of CBMA-incorporated PMMA are acceptable for clinical practice.

Original languageEnglish
Pages (from-to)194-204
Number of pages11
JournalJournal of Industrial and Engineering Chemistry
Publication statusPublished - 2020 Jun 25

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) and funded by the Ministry of Science, ICT and Future Planning ( NRF-2018R1C1B6000989 ).

Publisher Copyright:
© 2020 The Korean Society of Industrial and Engineering Chemistry

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)


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