Incidence of and risk factors for short stature in children with chronic kidney disease: results from the KNOW-Ped CKD

Eujin Park, Hye Jin Lee, Hyun Jin Choi, Yo Han Ahn, Kyoung Hee Han, Seong Heon Kim, Heeyeon Cho, Jae Il Shin, Joo Hoon Lee, Young Seo Park, Il Soo Ha, Min Hyun Cho, Hee Gyung Kang

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background: Preserving optimal growth has long been a significant concern for children with chronic kidney disease (CKD). We aimed to examine the incidence of and risk factors for short stature in Asian pediatric patients with CKD. Methods: We analyzed growth status by height, weight, and body mass index (BMI) standard deviation scores (SDSs) for 432 participants in the KoreaN cohort study for Outcome in patients With Pediatric Chronic Kidney Disease. Results: The median height, weight, and BMI SDSs were − 0.94 (interquartile range (IQR) − 1.95 to 0.05), − 0.58 (IQR − 1.46 to 0.48), and − 0.26 (IQR − 1.13 to 0.61), respectively. A high prevalence of short stature (101 of 432 patients, 23.4%) and underweight (61 of 432 patients, 14.1%) was observed. In multivariable logistic regression analysis, CKD stages 4 and 5 (adjusted odds ratio (aOR) 2.700, p = 0.001), onset before age 2 (aOR 2.928, p < 0.0001), underweight (aOR 2.353, p = 0.013), premature birth (aOR 3.484, p < 0.0001), LBW (aOR 3.496, p = 0.001), and low household income (aOR 1.935, p = 0.030) were independent risk factors associated with short stature in children with CKD. Conclusions: Children with CKD in Korea were shorter and had lower body weight and BMI than the general population. Short stature in children with CKD was most independently associated with low birth weight, followed by premature birth, onset before age 2, CKD stages 4 and 5, underweight, and low household income. Among these, underweight is the only modifiable factor. Therefore, we suggest children with CKD should be carefully monitored for weight, nutritional status, and body composition to achieve optimal growth. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)2857-2864
Number of pages8
JournalPediatric Nephrology
Issue number9
Publication statusPublished - 2021 Sept

Bibliographical note

Funding Information:
This study was supported by the Research Program funded by the Korea Centers for Disease Control and Prevention (fund codes 2011E3300300, 2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, 2016E3300200, 2016E3300201, 2016E3300202, 2019E320100, 2019E320101, and 2019E320102).

Publisher Copyright:
© 2021, IPNA.

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Nephrology


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