In Vivo Self-Powered Wireless Transmission Using Biocompatible Flexible Energy Harvesters

Dong Hyun Kim; Hong Ju Shin; Hyunseung Lee; Chang Kyu Jeong; Hyewon Park; Geon Tae Hwang; Ho Yong Lee; Daniel J. Joe; Jae Hyun Han; Seung Hyun Lee; Jaeha Kim; Boyoung Joung; Keon Jae Lee

doi:10.1002/adfm.201700341

In Vivo Self-Powered Wireless Transmission Using Biocompatible Flexible Energy Harvesters

Dong Hyun Kim, Hong Ju Shin, Hyunseung Lee, Chang Kyu Jeong, Hyewon Park, Geon Tae Hwang, Ho Yong Lee, Daniel J. Joe, Jae Hyun Han, Seung Hyun Lee, Jaeha Kim, Boyoung Joung, Keon Jae Lee

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

147 Citations (Scopus)

Abstract

Additional surgeries for implantable biomedical devices are inevitable to replace discharged batteries, but repeated surgeries can be a risk to patients, causing bleeding, inflammation, and infection. Therefore, developing self-powered implantable devices is essential to reduce the patient's physical/psychological pain and financial burden. Although wireless communication plays a critical role in implantable biomedical devices that contain the function of data transmitting, it has never been integrated with in vivo piezoelectric self-powered system due to its high-level power consumption (microwatt-scale). Here, wireless communication, which is essential for a ubiquitous healthcare system, is successfully driven with in vivo energy harvesting enabled by high-performance single-crystalline (1 − x)Pb(Mg_1/3Nb_2/3)O₃−(x)Pb(Zr,Ti)O₃ (PMN-PZT). The PMN-PZT energy harvester generates an open-circuit voltage of 17.8 V and a short-circuit current of 1.74 µA from porcine heartbeats, which are greater by a factor of 4.45 and 17.5 than those of previously reported in vivo piezoelectric energy harvesting. The energy harvester exhibits excellent biocompatibility, which implies the possibility for applying the device to biomedical applications.

Original language	English
Article number	1700341
Journal	Advanced Functional Materials
Volume	27
Issue number	25
DOIs	https://doi.org/10.1002/adfm.201700341
Publication status	Published - 2017 Jul 5

Bibliographical note

Funding Information:
D.H.K., H.J.S., and H.L. contributed equally to this work. This work was supported by research grants from the Korean Healthcare Technology R&D Project funded by the Ministry of Health & Welfare (Grant Nos. HI16C0058 and HI15C1200), and the by Nano Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (MSIP) (Grant No. 2016M3A7B4910636). This was also supported by the Global Frontier R&D Program on Center for Integrated Smart Sensors (Grant No. CISS-2016M3A6A6929958) funded by the MSIP through NRF of Korea government, and by the Wearable Platform Materials Technology Center (WMC) funded by the NRF Grant of the Korean Government (MSIP) (Grant No. 2016R1A5A1009926).

Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

All Science Journal Classification (ASJC) codes

Chemistry(all)
Materials Science(all)
Condensed Matter Physics

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10.1002/adfm.201700341

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title = "In Vivo Self-Powered Wireless Transmission Using Biocompatible Flexible Energy Harvesters",

abstract = "Additional surgeries for implantable biomedical devices are inevitable to replace discharged batteries, but repeated surgeries can be a risk to patients, causing bleeding, inflammation, and infection. Therefore, developing self-powered implantable devices is essential to reduce the patient's physical/psychological pain and financial burden. Although wireless communication plays a critical role in implantable biomedical devices that contain the function of data transmitting, it has never been integrated with in vivo piezoelectric self-powered system due to its high-level power consumption (microwatt-scale). Here, wireless communication, which is essential for a ubiquitous healthcare system, is successfully driven with in vivo energy harvesting enabled by high-performance single-crystalline (1 − x)Pb(Mg1/3Nb2/3)O3−(x)Pb(Zr,Ti)O3 (PMN-PZT). The PMN-PZT energy harvester generates an open-circuit voltage of 17.8 V and a short-circuit current of 1.74 µA from porcine heartbeats, which are greater by a factor of 4.45 and 17.5 than those of previously reported in vivo piezoelectric energy harvesting. The energy harvester exhibits excellent biocompatibility, which implies the possibility for applying the device to biomedical applications.",

author = "Kim, {Dong Hyun} and Shin, {Hong Ju} and Hyunseung Lee and Jeong, {Chang Kyu} and Hyewon Park and Hwang, {Geon Tae} and Lee, {Ho Yong} and Joe, {Daniel J.} and Han, {Jae Hyun} and Lee, {Seung Hyun} and Jaeha Kim and Boyoung Joung and Lee, {Keon Jae}",

note = "Funding Information: D.H.K., H.J.S., and H.L. contributed equally to this work. This work was supported by research grants from the Korean Healthcare Technology R&D Project funded by the Ministry of Health & Welfare (Grant Nos. HI16C0058 and HI15C1200), and the by Nano Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (MSIP) (Grant No. 2016M3A7B4910636). This was also supported by the Global Frontier R&D Program on Center for Integrated Smart Sensors (Grant No. CISS-2016M3A6A6929958) funded by the MSIP through NRF of Korea government, and by the Wearable Platform Materials Technology Center (WMC) funded by the NRF Grant of the Korean Government (MSIP) (Grant No. 2016R1A5A1009926). Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

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AU - Jeong, Chang Kyu

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AU - Hwang, Geon Tae

AU - Lee, Ho Yong

AU - Joe, Daniel J.

AU - Han, Jae Hyun

AU - Lee, Seung Hyun

AU - Kim, Jaeha

AU - Joung, Boyoung

AU - Lee, Keon Jae

N1 - Funding Information: D.H.K., H.J.S., and H.L. contributed equally to this work. This work was supported by research grants from the Korean Healthcare Technology R&D Project funded by the Ministry of Health & Welfare (Grant Nos. HI16C0058 and HI15C1200), and the by Nano Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (MSIP) (Grant No. 2016M3A7B4910636). This was also supported by the Global Frontier R&D Program on Center for Integrated Smart Sensors (Grant No. CISS-2016M3A6A6929958) funded by the MSIP through NRF of Korea government, and by the Wearable Platform Materials Technology Center (WMC) funded by the NRF Grant of the Korean Government (MSIP) (Grant No. 2016R1A5A1009926). Publisher Copyright: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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Y1 - 2017/7/5

N2 - Additional surgeries for implantable biomedical devices are inevitable to replace discharged batteries, but repeated surgeries can be a risk to patients, causing bleeding, inflammation, and infection. Therefore, developing self-powered implantable devices is essential to reduce the patient's physical/psychological pain and financial burden. Although wireless communication plays a critical role in implantable biomedical devices that contain the function of data transmitting, it has never been integrated with in vivo piezoelectric self-powered system due to its high-level power consumption (microwatt-scale). Here, wireless communication, which is essential for a ubiquitous healthcare system, is successfully driven with in vivo energy harvesting enabled by high-performance single-crystalline (1 − x)Pb(Mg1/3Nb2/3)O3−(x)Pb(Zr,Ti)O3 (PMN-PZT). The PMN-PZT energy harvester generates an open-circuit voltage of 17.8 V and a short-circuit current of 1.74 µA from porcine heartbeats, which are greater by a factor of 4.45 and 17.5 than those of previously reported in vivo piezoelectric energy harvesting. The energy harvester exhibits excellent biocompatibility, which implies the possibility for applying the device to biomedical applications.

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In Vivo Self-Powered Wireless Transmission Using Biocompatible Flexible Energy Harvesters

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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