In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment

Wonkeun Song; Borum Suh; Jun Yong Choi; Seok Hoon Jeong; Eun Hee Jeon; Young Ki Lee; Seong Geun Hong; Kyungwon Lee

doi:10.1016/j.diagmicrobio.2009.08.010

In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment

Wonkeun Song, Borum Suh, Jun Yong Choi, Seok Hoon Jeong, Eun Hee Jeon, Young Ki Lee, Seong Geun Hong, Kyungwon Lee

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC β-lactamase.

Original language	English
Pages (from-to)	447-449
Number of pages	3
Journal	Diagnostic Microbiology and Infectious Disease
Volume	65
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2009.08.010
Publication status	Published - 2009 Dec

Bibliographical note

Funding Information:
This work was supported by the Korea Research Foundation Grant (KRF-2008-E00194).

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.diagmicrobio.2009.08.010

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title = "In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment",

abstract = "We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC β-lactamase.",

author = "Wonkeun Song and Borum Suh and Choi, {Jun Yong} and Jeong, {Seok Hoon} and Jeon, {Eun Hee} and Lee, {Young Ki} and Hong, {Seong Geun} and Kyungwon Lee",

note = "Funding Information: This work was supported by the Korea Research Foundation Grant (KRF-2008-E00194).",

year = "2009",

month = dec,

doi = "10.1016/j.diagmicrobio.2009.08.010",

language = "English",

volume = "65",

pages = "447--449",

journal = "Diagnostic Microbiology and Infectious Disease",

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T1 - In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment

AU - Song, Wonkeun

AU - Suh, Borum

AU - Choi, Jun Yong

AU - Jeong, Seok Hoon

AU - Jeon, Eun Hee

AU - Lee, Young Ki

AU - Hong, Seong Geun

AU - Lee, Kyungwon

N1 - Funding Information: This work was supported by the Korea Research Foundation Grant (KRF-2008-E00194).

PY - 2009/12

Y1 - 2009/12

N2 - We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC β-lactamase.

AB - We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC β-lactamase.

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U2 - 10.1016/j.diagmicrobio.2009.08.010

DO - 10.1016/j.diagmicrobio.2009.08.010

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AN - SCOPUS:71549148077

SN - 0732-8893

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JO - Diagnostic Microbiology and Infectious Disease

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IS - 4

ER -

In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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