In vivo calibration of the subcutaneous amperometric glucose sensors using a non-enzyme electrode

Ran A. Jeong, Jae Youn Hwang, Segyeong Joo, Taek Dong Chung, Sejin Park, Sun Kil Kang, Won Yong Lee, Hee Chan Kim

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


A new two-point calibration method for the subcutaneous amperometric continuous glucose sensor is reported. The proposed method is based on direct measurement of the background current (Io) using a non-enzyme electrode. For in vivo test, three electrodes were implanted in rabbits. Two of the three were identical needle-type enzyme electrodes with perfluorinated polymer outer layers (Pt/enzyme layer/Kel-F/PTFE/Kel-F/Nafion) that were placed in subcutaneous tissue and in a vessel (ear artery), respectively. And one non-enzyme electrode with exactly the same membrane composition as those of other two was in the subcutaneous layer to measure the background current. Implantation in the subcutaneous layer generated many crevices on the protecting layers of the electrodes. The signals from enzyme electrodes were effectively corrected by the measured background current from the non-enzyme electrode. In addition, a telemetric monitoring system was developed and evaluated for in vivo continuous glucose monitoring in order to alleviate the problems of motion artifact.

Original languageEnglish
Pages (from-to)313-319
Number of pages7
JournalBiosensors and Bioelectronics
Issue number4
Publication statusPublished - 2003 Dec 15

Bibliographical note

Funding Information:
This work was supported by the Korea Science and Engineering Foundation through the Advanced Biometric Research Center.

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


Dive into the research topics of 'In vivo calibration of the subcutaneous amperometric glucose sensors using a non-enzyme electrode'. Together they form a unique fingerprint.

Cite this