In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma

Kyung Ah Koo; Sang Hyun Sung; Jong Hee Park; Seung Hyun Kim; Ki Yong Lee; Young Choong Kim

doi:10.1055/s-2005-871213

In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma

Kyung Ah Koo, Sang Hyun Sung, Jong Hee Park, Seung Hyun Kim, Ki Yong Lee, Young Choong Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

Ten phenylethanoid glycosides, forsythoside B, acteoside, 2′-acetylacteoside, poliumoside, brandioside, echinacoside, isoacteoside, cistanoside H and E-tubuloside E as well as a new compound, Z-tubuloside E, were isolated from the n-BuOH fraction of Callicarpa dichotoma Raeuschel (Verbenaceae) by bioactivity-guided fractionation using glutamate-injured primary cultures of rat cortical cells as a screening system. These phenylethanoid glycosides significantly attenuated glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM.

Original language	English
Pages (from-to)	778-780
Number of pages	3
Journal	Planta Medica
Volume	71
Issue number	8
DOIs	https://doi.org/10.1055/s-2005-871213
Publication status	Published - 2005 Aug

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1055/s-2005-871213

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abstract = "Ten phenylethanoid glycosides, forsythoside B, acteoside, 2′-acetylacteoside, poliumoside, brandioside, echinacoside, isoacteoside, cistanoside H and E-tubuloside E as well as a new compound, Z-tubuloside E, were isolated from the n-BuOH fraction of Callicarpa dichotoma Raeuschel (Verbenaceae) by bioactivity-guided fractionation using glutamate-injured primary cultures of rat cortical cells as a screening system. These phenylethanoid glycosides significantly attenuated glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM.",

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AU - Lee, Ki Yong

AU - Kim, Young Choong

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In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma

Abstract

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