In vitro cytotoxicity of covalently protected layered molybdenum disulfide

Nur Farhanah Rosli, Naziah M. Latiff, Zdeněk Sofer, Adrian C. Fisher, Martin Pumera

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16 Citations (Scopus)


Layered molybdenum disulfide (MoS2) is in forefront of materials research. MoS2 has been reported to display various unique electronic, catalytic and sensing properties. Functionalization of MoS2 is common as it can improve biocompatibility, electrochemical behaviour, catalytic performance, and sensing abilities. In this study, a cytotoxicity study of MoS2 functionalized with an organic molecule, thiobarbituric acid (TBA) was conducted. The functionalization of MoS2 with TBA (MoS2-TBA) is unique as it was reported to retain metallic 1T-type character which is important for electrochemical applications. In addition, MoS2-TBA could possibly be utilized to a wider range of applications as it can be further modified due to the presence of alcohol groups. Thus, investigating the toxicity of MoS2-TBA is essential since it has promising properties for several applications. Functionalized MoS2-TBA is expected to have different toxicity profile than non-functionalized MoS2 as several physicochemical properties may have changed after functionalization. The cytotoxicity study has been conducted via two common cell viability assays which are methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay and water-soluble tetrazolium salt (WST-8) assay. Human lung carcinoma epithelial cell line (A549) was chosen for this study it is highly probable for nanomaterials to enter the lungs and interact with the body via inhalation through the respiratory tract from the environment. This study has found that MoS2-TBA has become less toxic as compared to MoS2.

Original languageEnglish
Pages (from-to)200-206
Number of pages7
JournalApplied Materials Today
Publication statusPublished - 2018 Jun

Bibliographical note

Funding Information:
A. C. F. and N. F. R. thank C4T programme for funding. This project was funded by the National Research Foundation Singapore under its Campus for Research Excellence and Technological Enterprise (CREATE) programme. Z. S. was supported by Czech Science Foundation (GACR No. 15-07912S). This work was supported by the project Advanced Functional Nanorobots (Reg. No. CZ.02.1.01/0.0/0.0/15_003/0000444 financed by the EFRR ). This project was supported by Tier 99/13 grant by Ministry of Education, Singapore .

Publisher Copyright:
© 2018 Elsevier Ltd

All Science Journal Classification (ASJC) codes

  • Materials Science(all)


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