In vitro chemosensitivity test of SK-302B on human colon carcinoma cell lines

Soo Kie Kim; Chan Mug Ahn; Tae Ue Kim; Sun Ju Choi; Yoon Sun Park; Woon Seob Shin; Choon Myung Koh

doi:10.1007/BF02976237

In vitro chemosensitivity test of SK-302B on human colon carcinoma cell lines

Soo Kie Kim, Chan Mug Ahn, Tae Ue Kim, Sun Ju Choi, Yoon Sun Park, Woon Seob Shin, Choon Myung Koh

Microbiology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

SK-302B, an antibiotic purified from soil Streptomyces sp. 302, was structurally identified as echinomycin (C₅₀H₆₆N₁₁S₂). In the present experiment, the possibility of SK-302B as an anticolon cancer agent was investigated by using chemosensitivity system (MTT assay, clonogenic assay). Treatment of SK-302B on various colon cancer cell lines resulted in a significant cytotoxicity and tumor colony formation inhibition. These studies showed that SK-302B had a potent inhibition on colon cancer cells.

Original language	English
Pages (from-to)	261-263
Number of pages	3
Journal	Archives of pharmacal research
Volume	19
Issue number	4
DOIs	https://doi.org/10.1007/BF02976237
Publication status	Published - 1996 Aug

All Science Journal Classification (ASJC) codes

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/BF02976237

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title = "In vitro chemosensitivity test of SK-302B on human colon carcinoma cell lines",

abstract = "SK-302B, an antibiotic purified from soil Streptomyces sp. 302, was structurally identified as echinomycin (C50H66N11S2). In the present experiment, the possibility of SK-302B as an anticolon cancer agent was investigated by using chemosensitivity system (MTT assay, clonogenic assay). Treatment of SK-302B on various colon cancer cell lines resulted in a significant cytotoxicity and tumor colony formation inhibition. These studies showed that SK-302B had a potent inhibition on colon cancer cells.",

author = "Kim, {Soo Kie} and Ahn, {Chan Mug} and Kim, {Tae Ue} and Choi, {Sun Ju} and Park, {Yoon Sun} and Shin, {Woon Seob} and Koh, {Choon Myung}",

year = "1996",

month = aug,

doi = "10.1007/BF02976237",

language = "English",

volume = "19",

pages = "261--263",

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T1 - In vitro chemosensitivity test of SK-302B on human colon carcinoma cell lines

AU - Kim, Soo Kie

AU - Ahn, Chan Mug

AU - Kim, Tae Ue

AU - Choi, Sun Ju

AU - Park, Yoon Sun

AU - Shin, Woon Seob

AU - Koh, Choon Myung

PY - 1996/8

Y1 - 1996/8

N2 - SK-302B, an antibiotic purified from soil Streptomyces sp. 302, was structurally identified as echinomycin (C50H66N11S2). In the present experiment, the possibility of SK-302B as an anticolon cancer agent was investigated by using chemosensitivity system (MTT assay, clonogenic assay). Treatment of SK-302B on various colon cancer cell lines resulted in a significant cytotoxicity and tumor colony formation inhibition. These studies showed that SK-302B had a potent inhibition on colon cancer cells.

AB - SK-302B, an antibiotic purified from soil Streptomyces sp. 302, was structurally identified as echinomycin (C50H66N11S2). In the present experiment, the possibility of SK-302B as an anticolon cancer agent was investigated by using chemosensitivity system (MTT assay, clonogenic assay). Treatment of SK-302B on various colon cancer cell lines resulted in a significant cytotoxicity and tumor colony formation inhibition. These studies showed that SK-302B had a potent inhibition on colon cancer cells.

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SP - 261

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JO - Archives of pharmacal research

JF - Archives of pharmacal research

IS - 4

ER -

In vitro chemosensitivity test of SK-302B on human colon carcinoma cell lines

Abstract

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