A multifunctional intracellular pH-sensitive polymeric micelle carrier whose surface was conjugated with folic acid for active drug delivery was prepared and characterized in this study. Self-assembling amphiphilic block copolymers, folate-poly(ethylene glycol)-poly (aspartate hydrazone adriamycin) [Fol-PEG-P(Asp-Hyd-ADR)], were synthesized to prepare the micelles by developing a new synthetic method. Prepared micelle had an approximately 60 nm diameter. It is notable that a folate molecule was conjugated to the end of the shell-forming PEG chain while anticancer drugs, adriamycin (ADR) were bound to the side chain of the core-forming segment through an acid-sensitive hydrazone bond so that the micelle can selectively release the loaded ADR under intracellular acidic environment (pH 5-6) after folate-mediated intracellular trafficking. Obtained experimental results revealed that these micelles significantly improved cell growth inhibitory activity in spite of a short exposure time probably due to the selective and strong interaction between folate molecules and their receptors on the cell.
|Number of pages||2|
|Publication status||Published - 2005|
|Event||54th SPSJ Symposium on Macromolecules - Yamagata, Japan|
Duration: 2005 Sept 20 → 2005 Sept 22
|Other||54th SPSJ Symposium on Macromolecules|
|Period||05/9/20 → 05/9/22|
All Science Journal Classification (ASJC) codes