Improving the efficacy of chlorhexidine-releasing elastomerics using a layer-by-layer coating technique

Hyun Sun Jeon, Eun Ha Jung, Si Mook Kang, Eun Song Lee, Jeong Woo Lee, Baek Il Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The aims of this study were to identify the optimal concentration of coated orthodontic elastomerics using a layer-by-layer technique that can release chlorhexidine (CHX) as an antimicrobial material, and to measure the physical properties and antimicrobial effects of the coated elastomerics. Ethyl cellulose (EC) was used as the polymer, and five study groups with various combinations of solvents (i.e., ethanol and dichloromethane [DCM]) were included. The coated elastomerics were evaluated with a spectrophotometer to confirm the release of CHX, and their surfaces were observed by SEM. The CHX+EC+DCM group sustained antimicrobial release for the longest period (168 h, p<0.001) and exhibited the largest antimicrobial effect in an inhibition zone test using S. mutans for 7 days (p<0.05). This group had most effective physical properties and antimicrobial effects of coated elastomerics produced using a layer-by-layer technique, and so its composition should be considered for use in clinical applications in orthodontics.

Original languageEnglish
Pages (from-to)476-481
Number of pages6
JournalDental Materials Journal
Issue number4
Publication statusPublished - 2017

Bibliographical note

Funding Information:
This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education under grant (2016R1D1A1A09916934).

Publisher Copyright:
© 2017, Japanese Society for Dental Materials and Devices. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Ceramics and Composites
  • Dentistry(all)


Dive into the research topics of 'Improving the efficacy of chlorhexidine-releasing elastomerics using a layer-by-layer coating technique'. Together they form a unique fingerprint.

Cite this