Improved glucose tolerance and insulin sensitivity after electrical stimulation-assisted cycling in people with spinal cord injury

J. Y. Jeon; C. B. Weiss; R. D. Steadward; E. Ryan; R. S. Burnham; G. Bell; P. Chilibeck; G. D. Wheeler

doi:10.1038/sj.sc.3101260

Improved glucose tolerance and insulin sensitivity after electrical stimulation-assisted cycling in people with spinal cord injury

J. Y. Jeon, C. B. Weiss, R. D. Steadward, E. Ryan, R. S. Burnham, G. Bell, P. Chilibeck, G. D. Wheeler

Department of Sports Industry Studies

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Abstract

Design: Longitudinal training. Objectives: The purpose was to determine the effect of electrical stimulation (ES)-assisted cycling (30 min/day, 3 days/week for 8 weeks) on glucose tolerance and insulin sensitivity in people with spinal cord injury (SCI). Setting: The Steadward Centre, Alberta, Canada. Methods: Seven participants with motor complete SCI (five males and two females aged 30 to 53 years, injured 3-40 years, C5-T10) underwent 2-h oral glucose tolerance tests (OGTT, n = 7) and hyperglycaemic clamp tests (n = 3) before and after 8 weeks of training with ES-assisted cycling. Results: Results indicated that subjects' glucose level were significantly lower at 2 h OGTT following 8 weeks of training (122.4±10 vs 139.9±16, P=0.014). Two-hour hyperglycaemic clamps tests showed improvement in all three people for glucose utilisation and in two of three people for insulin sensitivity. Conclusions: These results suggested that exercise with ES-assisted cycling is beneficial for the prevention and treatment of Type 2 diabetes mellitus in people with SCI. Sponsorship: Supported by Alberta Paraplegic Foundation, Therapeutic Alliance.

Original language	English
Pages (from-to)	110-117
Number of pages	8
Journal	Spinal Cord
Volume	40
Issue number	3
DOIs	https://doi.org/10.1038/sj.sc.3101260
Publication status	Published - 2002

Bibliographical note

Funding Information:
Design: Longitudinal training. Objectives: The purpose was to determine the effect of electrical stimulation (ES)-assisted cycling (30 min/day, 3 days/week for 8 weeks) on glucose tolerance and insulin sensitivity in people with spinal cord injury (SCI). Setting: The Steadward Centre, Alberta, Canada. Methods: Seven participants with motor complete SCI (five males and two females aged 30 to 53 years, injured 3 – 40 years, C5 – T10) underwent 2-h oral glucose tolerance tests (OGTT, n=7) and hyperglycaemic clamp tests (n=3) before and after 8 weeks of training with ES-assisted cycling. Results: Results indicated that subjects' glucose level were significantly lower at 2 h OGTT following 8 weeks of training (122.4+10 vs 139.9+16, P=0.014). Two-hour hyperglycaemic clamps tests showed improvement in all three people for glucose utilisation and in two of three people for insulin sensitivity. Conclusions: These results suggested that exercise with ES-assisted cycling is beneficial for the prevention and treatment of Type 2 diabetes mellitus in people with SCI. Sponsorship: Supported by Alberta Paraplegic Foundation, Therapeutic Alliance. Spinal Cord (2002) 40, 110 – 117. DOI: 10.1038/sj/sc/3101260

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Neurology
Clinical Neurology

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title = "Improved glucose tolerance and insulin sensitivity after electrical stimulation-assisted cycling in people with spinal cord injury",

abstract = "Design: Longitudinal training. Objectives: The purpose was to determine the effect of electrical stimulation (ES)-assisted cycling (30 min/day, 3 days/week for 8 weeks) on glucose tolerance and insulin sensitivity in people with spinal cord injury (SCI). Setting: The Steadward Centre, Alberta, Canada. Methods: Seven participants with motor complete SCI (five males and two females aged 30 to 53 years, injured 3-40 years, C5-T10) underwent 2-h oral glucose tolerance tests (OGTT, n = 7) and hyperglycaemic clamp tests (n = 3) before and after 8 weeks of training with ES-assisted cycling. Results: Results indicated that subjects' glucose level were significantly lower at 2 h OGTT following 8 weeks of training (122.4±10 vs 139.9±16, P=0.014). Two-hour hyperglycaemic clamps tests showed improvement in all three people for glucose utilisation and in two of three people for insulin sensitivity. Conclusions: These results suggested that exercise with ES-assisted cycling is beneficial for the prevention and treatment of Type 2 diabetes mellitus in people with SCI. Sponsorship: Supported by Alberta Paraplegic Foundation, Therapeutic Alliance.",

author = "Jeon, {J. Y.} and Weiss, {C. B.} and Steadward, {R. D.} and E. Ryan and Burnham, {R. S.} and G. Bell and P. Chilibeck and Wheeler, {G. D.}",

note = "Funding Information: Design: Longitudinal training. Objectives: The purpose was to determine the effect of electrical stimulation (ES)-assisted cycling (30 min/day, 3 days/week for 8 weeks) on glucose tolerance and insulin sensitivity in people with spinal cord injury (SCI). Setting: The Steadward Centre, Alberta, Canada. Methods: Seven participants with motor complete SCI (five males and two females aged 30 to 53 years, injured 3 – 40 years, C5 – T10) underwent 2-h oral glucose tolerance tests (OGTT, n=7) and hyperglycaemic clamp tests (n=3) before and after 8 weeks of training with ES-assisted cycling. Results: Results indicated that subjects' glucose level were significantly lower at 2 h OGTT following 8 weeks of training (122.4+10 vs 139.9+16, P=0.014). Two-hour hyperglycaemic clamps tests showed improvement in all three people for glucose utilisation and in two of three people for insulin sensitivity. Conclusions: These results suggested that exercise with ES-assisted cycling is beneficial for the prevention and treatment of Type 2 diabetes mellitus in people with SCI. Sponsorship: Supported by Alberta Paraplegic Foundation, Therapeutic Alliance. Spinal Cord (2002) 40, 110 – 117. DOI: 10.1038/sj/sc/3101260",

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AU - Jeon, J. Y.

AU - Weiss, C. B.

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AU - Ryan, E.

AU - Burnham, R. S.

AU - Bell, G.

AU - Chilibeck, P.

AU - Wheeler, G. D.

N1 - Funding Information: Design: Longitudinal training. Objectives: The purpose was to determine the effect of electrical stimulation (ES)-assisted cycling (30 min/day, 3 days/week for 8 weeks) on glucose tolerance and insulin sensitivity in people with spinal cord injury (SCI). Setting: The Steadward Centre, Alberta, Canada. Methods: Seven participants with motor complete SCI (five males and two females aged 30 to 53 years, injured 3 – 40 years, C5 – T10) underwent 2-h oral glucose tolerance tests (OGTT, n=7) and hyperglycaemic clamp tests (n=3) before and after 8 weeks of training with ES-assisted cycling. Results: Results indicated that subjects' glucose level were significantly lower at 2 h OGTT following 8 weeks of training (122.4+10 vs 139.9+16, P=0.014). Two-hour hyperglycaemic clamps tests showed improvement in all three people for glucose utilisation and in two of three people for insulin sensitivity. Conclusions: These results suggested that exercise with ES-assisted cycling is beneficial for the prevention and treatment of Type 2 diabetes mellitus in people with SCI. Sponsorship: Supported by Alberta Paraplegic Foundation, Therapeutic Alliance. Spinal Cord (2002) 40, 110 – 117. DOI: 10.1038/sj/sc/3101260

PY - 2002

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N2 - Design: Longitudinal training. Objectives: The purpose was to determine the effect of electrical stimulation (ES)-assisted cycling (30 min/day, 3 days/week for 8 weeks) on glucose tolerance and insulin sensitivity in people with spinal cord injury (SCI). Setting: The Steadward Centre, Alberta, Canada. Methods: Seven participants with motor complete SCI (five males and two females aged 30 to 53 years, injured 3-40 years, C5-T10) underwent 2-h oral glucose tolerance tests (OGTT, n = 7) and hyperglycaemic clamp tests (n = 3) before and after 8 weeks of training with ES-assisted cycling. Results: Results indicated that subjects' glucose level were significantly lower at 2 h OGTT following 8 weeks of training (122.4±10 vs 139.9±16, P=0.014). Two-hour hyperglycaemic clamps tests showed improvement in all three people for glucose utilisation and in two of three people for insulin sensitivity. Conclusions: These results suggested that exercise with ES-assisted cycling is beneficial for the prevention and treatment of Type 2 diabetes mellitus in people with SCI. Sponsorship: Supported by Alberta Paraplegic Foundation, Therapeutic Alliance.

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Improved glucose tolerance and insulin sensitivity after electrical stimulation-assisted cycling in people with spinal cord injury

Abstract

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