Improved estimation of myelin water fraction using complex model fitting

Yoonho Nam, Jongho Lee, Dosik Hwang, Dong Hyun Kim

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)


In gradient echo (GRE) imaging, three compartment water modeling (myelin water, axonal water and extracellular water) in white matter has been demonstrated to show different frequency shifts that depend on the relative orientation of fibers and the B0 field. This finding suggests that in GRE-based myelin water imaging, a signal model may need to incorporate frequency offset terms and become a complex-valued model. In the current study, three different signal models and fitting approaches (a magnitude model fitted to magnitude data, a complex model fitted to magnitude data, and a complex model fitted to complex data) were investigated to address the reliability of each model in the estimation of the myelin water signal. For the complex model fitted to complex data, a new fitting approach that does not require background phase removal was proposed. When the three models were compared, the results from the new complex model fitting showed the most stable parameter estimation.

Original languageEnglish
Pages (from-to)214-221
Number of pages8
Publication statusPublished - 2015 Aug 1

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government ( MEST ) ( NRF-2012R1A2A2A01009903 ).

Publisher Copyright:
© 2015 Elsevier Inc.

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience


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