Implantation and control of wireless, battery-free systems for peripheral nerve interfacing

Hongkai Wang, Dom D’andrea, Yeon Sik Choi, Yasmine Bouricha, Grace Wickerson, Hak Young Ahn, Hexia Guo, Yonggang Huang, Milap S. Sandhu, Sumanas W. Jordan, John A. Rogers, Colin K. Franz

Research output: Contribution to journalArticlepeer-review


Peripheral nerve interfaces are frequently used in experimental neuroscience and regenerative medicine for a wide variety of applications. Such interfaces can be sensors, actuators, or both. Traditional methods of peripheral nerve interfacing must either tether to an external system or rely on battery power that limits the time frame for operation. With recent developments of wireless, battery-free, and fully implantable peripheral nerve interfaces, a new class of devices can offer capabilities that match or exceed those of their wired or battery-powered precursors. This paper describes methods to (i) surgically implant and (ii) wirelessly power and control this system in adult rats. The sciatic and phrenic nerve models were selected as examples to highlight the versatility of this approach. The paper shows how the peripheral nerve interface can evoke compound muscle action potentials (CMAPs), deliver a therapeutic electrical stimulation protocol, and incorporate a conduit for the repair of peripheral nerve injury. Such devices offer expanded treatment options for single-dose or repeated dose therapeutic stimulation and can be adapted to a variety of nerve locations.

Original languageEnglish
Article numbere63085
JournalJournal of Visualized Experiments
Issue number176
Publication statusPublished - 2021 Oct

Bibliographical note

Publisher Copyright:
© 2021 JoVE Journal of Visualized Experiments.

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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