Impacts of leuprolide acetate on quality of life in patients with prostate cancer: A prospective multicenter study

Dalsan You, In Gab Jeong, Sae Woong Kim, Byung Ha Chung, Jin Seon Cho, Hyun Moo Lee, Sung Cheol Yun, Choung Soo Kim

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9 Citations (Scopus)


Objective. To investigate the impacts of leuprolide acetate on the quality of life (QoL) of patients with prostate cancer. Material and methods. A total of 104 patients was enrolled in this prospective multicenter study. All patients received subcutaneous injections of 3.75 mg leuprolide acetate at 4 week intervals for a total of 12 weeks. QoL was assessed before treatment and at 12 weeks using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and an accompanying prostate cancer-specific module (QLQ-PR25). Results. Eighty-nine of 104 patients (85.6%) completed the 12 week study. Eighty-six of 89 patients (96.6%) achieved and maintained medical castration. The results of the EORTC QLQ-C30 indicated that patients experienced an improvement in global health status/QoL (p < 0.001), despite a deterioration in physical and role functioning (p=0.012 and p=0.007, respectively). The symptom scales indicated a statistically significant improvement in appetite (p=0.003). The results of the QLQ-PR25 revealed that patients experienced an increase in hot flushes (p < 0.001) and erection problems and uncomfortable sexual intimacy among the sexual functioning items (p=0.030 and p=0.023, respectively), but day-time urinary frequency was improved (p=0.004). Conclusion. The results of this prospective study indicate that leuprolide acetate treatment was accompanied by improvements in global health status/QoL, despite a deterioration in physical, role and sexual function.

Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalScandinavian Journal of Urology and Nephrology
Issue number6
Publication statusPublished - 2010 Dec

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology


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