Impact of psychological and cancer-related factors on HRQoL for Korean childhood cancer survivors

Myung Ah Rhee, Kyong Mee Chung, Yuri Lee, Hana K. Choi, Jung Woo Han, Hyo Sun Kim, Sun Hee Kim, Yoon Jung Shin, Chuhl Joo Lyu

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Purpose: The purposes of this study were (1) to compare health-related quality of life (HRQoL) between Korean childhood cancer survivors and healthy controls and (2) to examine the impact of demographic, diagnosis/treatment, and psychological variables on physical and psychosocial health in survivors.

Methods: The HRQoL (PedsQL), Self-Concept Inventory, and Child Behavior Checklist were administered to childhood cancer survivors, age/gender-matched healthy counterparts, and their parents. Independent-samples t tests and hierarchical multiple regression analyses were conducted.

Results: Compared with healthy controls, childhood cancer survivors reported significantly lower scores across physical and psychosocial HRQoL. For survivors, demographic, diagnosis/treatment, current health status, and psychological variables explained more than 50 % of the variance in both subscales of HRQoL. Especially, self-concept, a psychological variable, explained a significant portion of the variance in physical and psychosocial HRQoL after controlling for cancer-related factors. Several cancer-related factors including time since treatment completion, having a history of allogeneic hematopoietic stem cell transplantation, multiple treatment modalities, and suffering from severe late effects also associated with specific dimension of HRQoL.

Conclusions: Childhood cancer survivors do experience lower level of QoL and psychological factors, especially self-concept, should be considered when supporting the well-being of childhood cancer survivors.

Original languageEnglish
Pages (from-to)2603-2612
Number of pages10
JournalQuality of Life Research
Issue number9
Publication statusPublished - 2014 Oct 7

Bibliographical note

Publisher Copyright:
© 2014, Springer International Publishing Switzerland.

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health


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