Impact of heart rate reduction with maximal tolerable dose of bisoprolol on left ventricular reverse remodeling

Suk Won Choi, Seongwoo Han, Wan Joo Shim, Dong Ju Choi, Yong Jin Kim, Byung Su Yoo, Kyung Kuk Hwang, Hui Kyung Jeon, Mi Seung Shin, Kyu Hyung Ryu

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4 Citations (Scopus)


Background: We aimed to evaluate effect of heart rate (HR) reduction on left ventricular reverse remodeling (LVRR) in Korean patients with heart failure with reduced ejection fraction (HFrEF). Methods: Ambulatory patients with HFrEF, who had paired echocardiograms, N-terminal prohormone brain natriuretic peptide (NT-proBNP), and global assessment score (GAS) at baseline and 6-month (n = 157), were followed up on preset treatment schedule with bisoprolol. Results: The LVRR occurred in 49 patients (32%) at 6-month. In multivariable analysis, independent predictors associated with LVRR were use of anti-aldosterone agent (odds ratio [OR], 4.18; 95% confidence interval [CI], 1.80-9.71), young age (OR, 0.96; 95% CI, 0.92-0.99), high baseline HR (OR, 3.76; 95% CI, 1.40-10.10), and favorable baseline GAS (OR, 1.73; 95% CI, 1.06-2.81). Beneficial effect of bisoprolol, in terms of LVRR, NT-proBNP, and GAS, was remarkable in the high HR group (baseline HR = 75 beats per minute [bpm]), which showed a large HR reduction. Conclusion: High baseline HR (≥ 75 bpm) showed an association with LVRR and improvement of NT-proBNP and GAS in patients with HFrEF. This seems to be due to a large HR reduction after treatments with bisoprolol. Trial registry at, NCT00749034.

Original languageEnglish
Article numbere171
JournalJournal of Korean medical science
Issue number25
Publication statusPublished - 2018 Jun 1

Bibliographical note

Publisher Copyright:
© 2018 The Korean Academy of Medical Sciences.

All Science Journal Classification (ASJC) codes

  • General Medicine


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