Immunotherapy in the treatment of non-small cell lung cancer

Raghav Sundar, Richie Soong, Byoung Chul Cho, Julie R. Brahmer, Ross A. Soo

Research output: Contribution to journalReview articlepeer-review

98 Citations (Scopus)


Advances in the understanding of the role of the immune system in tumor immunosurveillance have resulted in the recognition that tumors can evade immune destruction via the dysregulation of co-inhibitory or checkpoint signals. This has led to the development of a generation immunotherapeutic agents targeting the immune checkpoint pathway. Recent early phase studies of immune checkpoint modulators, such as CTLA-4, PD-1 and PD-L1 inhibitors in NSCLC have reported promising results with prolonged clinical responses and tolerable toxicity. This article provides an overview of co-stimulatory and inhibitory molecules that regulate the immune response to tumors, recent therapies that have been developed to exploit these interactions and the role of predictive biomarkers in treatment selection.

Original languageEnglish
Pages (from-to)101-109
Number of pages9
JournalLung Cancer
Issue number2
Publication statusPublished - 2014 Aug

Bibliographical note

Funding Information:
RAS is supported by the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research


Dive into the research topics of 'Immunotherapy in the treatment of non-small cell lung cancer'. Together they form a unique fingerprint.

Cite this