Immunomodulatory roles of PE/PPE proteins and their implications in genomic features of Mycobacterium tuberculosis

Soo Young Choi; Sung Jae Shin

doi:10.4167/jbv.2015.45.3.272

Immunomodulatory roles of PE/PPE proteins and their implications in genomic features of Mycobacterium tuberculosis

Soo Young Choi, Sung Jae Shin

Department of Microbiology

Research output: Contribution to journal › Review article › peer-review

Abstract

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a notorious cause of human death worldwide. A deeper understanding of the proline-glutamate (PE) and proline-proline-glutamate (PPE) families, which compromise 10% of the coding regions in the Mtb genome, has uncovered their unique roles in host-pathogen interactions. Further, comparative genomic analysis of different Mtb strains has proposed that Mtb has acquired diverse gene sets that play immunomodulatory roles in host-pathogen interactions. This review delineates the various immunomodulatory roles of PE/PPE antigens and discusses their implications in the development of the improved diagnostic tools and vaccines.

Original language	English
Pages (from-to)	272-281
Number of pages	10
Journal	Journal of Bacteriology and Virology
Volume	45
Issue number	3
DOIs	https://doi.org/10.4167/jbv.2015.45.3.272
Publication status	Published - 2015

Bibliographical note

Publisher Copyright:
© 2015, Chonnam National University Medical School. All rights reserved.

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4167/jbv.2015.45.3.272

Cite this

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abstract = "Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a notorious cause of human death worldwide. A deeper understanding of the proline-glutamate (PE) and proline-proline-glutamate (PPE) families, which compromise 10% of the coding regions in the Mtb genome, has uncovered their unique roles in host-pathogen interactions. Further, comparative genomic analysis of different Mtb strains has proposed that Mtb has acquired diverse gene sets that play immunomodulatory roles in host-pathogen interactions. This review delineates the various immunomodulatory roles of PE/PPE antigens and discusses their implications in the development of the improved diagnostic tools and vaccines.",

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AB - Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a notorious cause of human death worldwide. A deeper understanding of the proline-glutamate (PE) and proline-proline-glutamate (PPE) families, which compromise 10% of the coding regions in the Mtb genome, has uncovered their unique roles in host-pathogen interactions. Further, comparative genomic analysis of different Mtb strains has proposed that Mtb has acquired diverse gene sets that play immunomodulatory roles in host-pathogen interactions. This review delineates the various immunomodulatory roles of PE/PPE antigens and discusses their implications in the development of the improved diagnostic tools and vaccines.

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Immunomodulatory roles of PE/PPE proteins and their implications in genomic features of Mycobacterium tuberculosis

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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