Immunohistochemical localization of 2-Cys peroxiredoxins in human ciliary body

Samin Hong; Chan Yun Kim; Joon H. Lee; Gong Je Seong

doi:10.1016/j.tice.2007.06.003

Immunohistochemical localization of 2-Cys peroxiredoxins in human ciliary body

Samin Hong, Chan Yun Kim, Joon H. Lee, Gong Je Seong

Department of Ophthalmology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

2-Cys peroxiredoxins (PRDX) are novel antioxidant enzymes that eliminate the hydrogen peroxide in cells to protect the cellular components from reactive oxygen species. To evaluate whether 2-Cys PRDX family plays a role in human ciliary body, the expression of PRDX I, II and III on normal human ciliary body was investigated. Three normal human ciliary body tissues obtained from three donor eyeballs were examined by an immunohistochemistry using light microscopy and fluorescent microscopy with antibodies directed against the PRDX I, II and III. In the normal human ciliary body, PRDX I, II and III were immunolocalized to the non-pigmented epithelial cells and ciliary muscle fibers. It suggests that 2-Cys PRDXs may have physiological functions to protect cells in human ciliary body.

Original language	English
Pages (from-to)	365-368
Number of pages	4
Journal	Tissue and Cell
Volume	39
Issue number	5
DOIs	https://doi.org/10.1016/j.tice.2007.06.003
Publication status	Published - 2007 Oct

Bibliographical note

Funding Information:
This work was supported by the Students’ Association of the Graduate School of Yonsei University funded by the Graduate School of Yonsei University, Seoul, Republic of Korea.

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

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10.1016/j.tice.2007.06.003

Cite this

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title = "Immunohistochemical localization of 2-Cys peroxiredoxins in human ciliary body",

abstract = "2-Cys peroxiredoxins (PRDX) are novel antioxidant enzymes that eliminate the hydrogen peroxide in cells to protect the cellular components from reactive oxygen species. To evaluate whether 2-Cys PRDX family plays a role in human ciliary body, the expression of PRDX I, II and III on normal human ciliary body was investigated. Three normal human ciliary body tissues obtained from three donor eyeballs were examined by an immunohistochemistry using light microscopy and fluorescent microscopy with antibodies directed against the PRDX I, II and III. In the normal human ciliary body, PRDX I, II and III were immunolocalized to the non-pigmented epithelial cells and ciliary muscle fibers. It suggests that 2-Cys PRDXs may have physiological functions to protect cells in human ciliary body.",

author = "Samin Hong and {Yun Kim}, Chan and Lee, {Joon H.} and Seong, {Gong Je}",

note = "Funding Information: This work was supported by the Students{\textquoteright} Association of the Graduate School of Yonsei University funded by the Graduate School of Yonsei University, Seoul, Republic of Korea.",

year = "2007",

month = oct,

doi = "10.1016/j.tice.2007.06.003",

language = "English",

volume = "39",

pages = "365--368",

journal = "Tissue and Cell",

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T1 - Immunohistochemical localization of 2-Cys peroxiredoxins in human ciliary body

AU - Hong, Samin

AU - Yun Kim, Chan

AU - Lee, Joon H.

AU - Seong, Gong Je

N1 - Funding Information: This work was supported by the Students’ Association of the Graduate School of Yonsei University funded by the Graduate School of Yonsei University, Seoul, Republic of Korea.

PY - 2007/10

Y1 - 2007/10

N2 - 2-Cys peroxiredoxins (PRDX) are novel antioxidant enzymes that eliminate the hydrogen peroxide in cells to protect the cellular components from reactive oxygen species. To evaluate whether 2-Cys PRDX family plays a role in human ciliary body, the expression of PRDX I, II and III on normal human ciliary body was investigated. Three normal human ciliary body tissues obtained from three donor eyeballs were examined by an immunohistochemistry using light microscopy and fluorescent microscopy with antibodies directed against the PRDX I, II and III. In the normal human ciliary body, PRDX I, II and III were immunolocalized to the non-pigmented epithelial cells and ciliary muscle fibers. It suggests that 2-Cys PRDXs may have physiological functions to protect cells in human ciliary body.

AB - 2-Cys peroxiredoxins (PRDX) are novel antioxidant enzymes that eliminate the hydrogen peroxide in cells to protect the cellular components from reactive oxygen species. To evaluate whether 2-Cys PRDX family plays a role in human ciliary body, the expression of PRDX I, II and III on normal human ciliary body was investigated. Three normal human ciliary body tissues obtained from three donor eyeballs were examined by an immunohistochemistry using light microscopy and fluorescent microscopy with antibodies directed against the PRDX I, II and III. In the normal human ciliary body, PRDX I, II and III were immunolocalized to the non-pigmented epithelial cells and ciliary muscle fibers. It suggests that 2-Cys PRDXs may have physiological functions to protect cells in human ciliary body.

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SN - 0040-8166

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JO - Tissue and Cell

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Immunohistochemical localization of 2-Cys peroxiredoxins in human ciliary body

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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