Immunogenicity of COVID-19 vaccines in patients with diverse health conditions: A comprehensive systematic review

Kyuyeon Cho, Seoyeon Park, Eun Young Kim, Ai Koyanagi, Louis Jacob, Dong K. Yon, Seung Won Lee, Min Seo Kim, Joaquim Radua, Dragioti Elena, Jae Il Shin, Lee Smith

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


It remains unclear how effective COVID-19 vaccinations will be in patients with weakened immunity due to diseases, transplantation, and dialysis. We conducted a systematic review comparing the efficacy of COVID-19 vaccination in patients with solid tumor, hematologic malignancy, autoimmune disease, inflammatory bowel disease, and patients who received transplantation or dialysis. A literature search was conducted twice using the Medline/PubMed database. As a result, 21 papers were included in the review, and seropositivity rate was summarized by specific type of disease, transplantation, and dialysis. When different papers studied the same type of patient group, a study with a higher number of participants was selected. Most of the solid tumor patients showed a seropositivity rate of more than 80% after the second inoculation, but a low seropositivity was found in certain tumors such as breast cancer. Research in patients with certain types of hematological malignancy and autoimmune diseases has also reported low seropositivity, and this may have been affected by the immunosuppressive treatment these patients receive. Research in patients receiving dialysis or transplantation has reported lower seropositivity rates than the general population, while all patients with inflammatory bowel disease have converted to be seropositive. Meta-analysis validating these results will be needed, and studies will also be needed on methods to protect patients with reduced immunity from COVID-19.

Original languageEnglish
Pages (from-to)4144-4155
Number of pages12
JournalJournal of Medical Virology
Issue number9
Publication statusPublished - 2022 Sept

Bibliographical note

Funding Information:
None provided financial support for the conduct of the research and/or preparation of the article.

Publisher Copyright:
© 2022 Wiley Periodicals LLC.

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases


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