Immune-modulating effect of korean red ginseng by balancing the ratio of peripheral T lymphocytes in bile duct or pancreatic cancer patients with adjuvant chemotherapy

Im Kyung Kim, Kang Young Lee, Jeonghyun Kang, Joon Seong Park, Joon Jeong

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background/Aim: We aimed to clarify the clinical effect of Korean Red ginseng administered with adjuvant chemotherapy on the immune function of patients with bile duct or pancreatic cancer. Patients and Methods: This was a prospective, randomized controlled trial conducted at a single tertiary center. Twenty-six consecutive patients who underwent curative resection for bile duct or pancreatic cancer followed by 5-fluorouracil/leucovorin or gemcitabine chemotherapy were included. They were randomized 1:1 to the ginseng and control groups. Immune and inflammatory markers were assayed in peripheral blood samples during and after chemotherapy. Results: Intergroup differences in immune-related parameters before and during chemotherapy were not significant. After chemotherapy, the percentage of CD4+T lymphocytes was significantly higher in the ginseng group than in the control group (42.01% vs. 33.69%, p=0.048). The ratio of CD4+/CD8+T lymphocytes was also higher in the ginseng group (2.03 vs. 1.28, p=0.027). Neutropenia and liver dysfunction prevalence did not differ between the groups. Conclusion: The ginseng group, which received Korean Red ginseng daily during adjuvant chemotherapy, showed higher levels of CD4+T lymphocytes and CD4+/CD8+T lymphocyte ratio after chemotherapy.

Original languageEnglish
Pages (from-to)1895-1900
Number of pages6
JournalIn Vivo
Volume35
Issue number3
DOIs
Publication statusPublished - 2021 May

Bibliographical note

Publisher Copyright:
© 2021 International Institute of Anticancer Research. All rights reserved.

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • Pharmacology

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