Identification of skin aging biomarkers correlated with the biomechanical properties

Seo Hyeong Kim; Ji Hye Kim; Jang Mi Suk; Young In Lee; Jihee Kim; Ju Hee Lee; Kwang Hoon Lee

doi:10.1111/srt.13046

Identification of skin aging biomarkers correlated with the biomechanical properties

Seo Hyeong Kim, Ji Hye Kim, Jang Mi Suk, Young In Lee, Jihee Kim, Ju Hee Lee, Kwang Hoon Lee

Department of Dermatology

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Background: Skin aging can be described as a combination of intrinsic and extrinsic aging. Various parameters for evaluating skin characteristics have been proposed. However, an accurate biomarker for skin aging and the relationship between biomarkers and biomechanical parameters of the skin is yet to be explored. Materials and Methods: This study included 20 subjects by age. Skin aging was measured using non-invasive devices. Skin tissues were acquired through punch biopsy for immunohistochemistry and qRT-PCR of skin aging biomarkers, and analyzed correlation both, validated their use. Results: Biomechanical properties of skin aging decreased with age. Among the biomarkers previously reported, we found that the expression of Moesin, TXNDC5, RhoGDI, and RSU1 decreased, while that of Vimentin and FABP5 increased with age. Pearson correlation showed that the expression levels of TXNDC5, RhoGDI, RSU1, and Vimentin were significantly correlated with the results of non-invasive measurements. In addition, the expression of TXNDC5, RhoGDI, and RSU1 increased, while that of Vimentin decreased, in skin explants upon treatment with one of the anti-aging compounds, retinoic acid. Conclusion: From this study, we identified practical molecular biomarkers of skin aging, TXNDC5, RhoGDI, RSU1, and Vimentin, which correlated with the skin biomechanical properties of skin aging.

Original language	English
Pages (from-to)	940-947
Number of pages	8
Journal	Skin Research and Technology
Volume	27
Issue number	5
DOIs	https://doi.org/10.1111/srt.13046
Publication status	Published - 2021 Sept

Bibliographical note

Funding Information:
This work was supported by the Technology Development Program (S2652600) funded by the Ministry of SMEs and Startups (MSS, Korea). This study is partially supported by the Yonsei University Faculty Research Grant (No. 6‐2020‐0081).

Publisher Copyright:
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

All Science Journal Classification (ASJC) codes

Dermatology

Access to Document

10.1111/srt.13046

Cite this

@article{1e9b82b595b449c0844402a3c6f95b34,

title = "Identification of skin aging biomarkers correlated with the biomechanical properties",

abstract = "Background: Skin aging can be described as a combination of intrinsic and extrinsic aging. Various parameters for evaluating skin characteristics have been proposed. However, an accurate biomarker for skin aging and the relationship between biomarkers and biomechanical parameters of the skin is yet to be explored. Materials and Methods: This study included 20 subjects by age. Skin aging was measured using non-invasive devices. Skin tissues were acquired through punch biopsy for immunohistochemistry and qRT-PCR of skin aging biomarkers, and analyzed correlation both, validated their use. Results: Biomechanical properties of skin aging decreased with age. Among the biomarkers previously reported, we found that the expression of Moesin, TXNDC5, RhoGDI, and RSU1 decreased, while that of Vimentin and FABP5 increased with age. Pearson correlation showed that the expression levels of TXNDC5, RhoGDI, RSU1, and Vimentin were significantly correlated with the results of non-invasive measurements. In addition, the expression of TXNDC5, RhoGDI, and RSU1 increased, while that of Vimentin decreased, in skin explants upon treatment with one of the anti-aging compounds, retinoic acid. Conclusion: From this study, we identified practical molecular biomarkers of skin aging, TXNDC5, RhoGDI, RSU1, and Vimentin, which correlated with the skin biomechanical properties of skin aging.",

author = "Kim, {Seo Hyeong} and Kim, {Ji Hye} and Suk, {Jang Mi} and Lee, {Young In} and Jihee Kim and Lee, {Ju Hee} and Lee, {Kwang Hoon}",

note = "Funding Information: This work was supported by the Technology Development Program (S2652600) funded by the Ministry of SMEs and Startups (MSS, Korea). This study is partially supported by the Yonsei University Faculty Research Grant (No. 6‐2020‐0081). Publisher Copyright: {\textcopyright} 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2021",

month = sep,

doi = "10.1111/srt.13046",

language = "English",

volume = "27",

pages = "940--947",

journal = "Skin Research and Technology",

issn = "0909-752X",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Identification of skin aging biomarkers correlated with the biomechanical properties

AU - Kim, Seo Hyeong

AU - Kim, Ji Hye

AU - Suk, Jang Mi

AU - Lee, Young In

AU - Kim, Jihee

AU - Lee, Ju Hee

AU - Lee, Kwang Hoon

N1 - Funding Information: This work was supported by the Technology Development Program (S2652600) funded by the Ministry of SMEs and Startups (MSS, Korea). This study is partially supported by the Yonsei University Faculty Research Grant (No. 6‐2020‐0081). Publisher Copyright: © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2021/9

Y1 - 2021/9

N2 - Background: Skin aging can be described as a combination of intrinsic and extrinsic aging. Various parameters for evaluating skin characteristics have been proposed. However, an accurate biomarker for skin aging and the relationship between biomarkers and biomechanical parameters of the skin is yet to be explored. Materials and Methods: This study included 20 subjects by age. Skin aging was measured using non-invasive devices. Skin tissues were acquired through punch biopsy for immunohistochemistry and qRT-PCR of skin aging biomarkers, and analyzed correlation both, validated their use. Results: Biomechanical properties of skin aging decreased with age. Among the biomarkers previously reported, we found that the expression of Moesin, TXNDC5, RhoGDI, and RSU1 decreased, while that of Vimentin and FABP5 increased with age. Pearson correlation showed that the expression levels of TXNDC5, RhoGDI, RSU1, and Vimentin were significantly correlated with the results of non-invasive measurements. In addition, the expression of TXNDC5, RhoGDI, and RSU1 increased, while that of Vimentin decreased, in skin explants upon treatment with one of the anti-aging compounds, retinoic acid. Conclusion: From this study, we identified practical molecular biomarkers of skin aging, TXNDC5, RhoGDI, RSU1, and Vimentin, which correlated with the skin biomechanical properties of skin aging.

AB - Background: Skin aging can be described as a combination of intrinsic and extrinsic aging. Various parameters for evaluating skin characteristics have been proposed. However, an accurate biomarker for skin aging and the relationship between biomarkers and biomechanical parameters of the skin is yet to be explored. Materials and Methods: This study included 20 subjects by age. Skin aging was measured using non-invasive devices. Skin tissues were acquired through punch biopsy for immunohistochemistry and qRT-PCR of skin aging biomarkers, and analyzed correlation both, validated their use. Results: Biomechanical properties of skin aging decreased with age. Among the biomarkers previously reported, we found that the expression of Moesin, TXNDC5, RhoGDI, and RSU1 decreased, while that of Vimentin and FABP5 increased with age. Pearson correlation showed that the expression levels of TXNDC5, RhoGDI, RSU1, and Vimentin were significantly correlated with the results of non-invasive measurements. In addition, the expression of TXNDC5, RhoGDI, and RSU1 increased, while that of Vimentin decreased, in skin explants upon treatment with one of the anti-aging compounds, retinoic acid. Conclusion: From this study, we identified practical molecular biomarkers of skin aging, TXNDC5, RhoGDI, RSU1, and Vimentin, which correlated with the skin biomechanical properties of skin aging.

UR - http://www.scopus.com/inward/record.url?scp=85104748077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85104748077&partnerID=8YFLogxK

U2 - 10.1111/srt.13046

DO - 10.1111/srt.13046

M3 - Article

C2 - 33891336

AN - SCOPUS:85104748077

SN - 0909-752X

VL - 27

SP - 940

EP - 947

JO - Skin Research and Technology

JF - Skin Research and Technology

IS - 5

ER -

Identification of skin aging biomarkers correlated with the biomechanical properties

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this