Hypothalamic control of energy expenditure and thermogenesis

Le Trung Tran, Sohee Park, Seul Ki Kim, Jin Sun Lee, Ki Woo Kim, Obin Kwon

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)


Energy expenditure and energy intake need to be balanced to maintain proper energy homeostasis. Energy homeostasis is tightly regulated by the central nervous system, and the hypothalamus is the primary center for the regulation of energy balance. The hypothalamus exerts its effect through both humoral and neuronal mechanisms, and each hypothalamic area has a distinct role in the regulation of energy expenditure. Recent studies have advanced the understanding of the molecular regulation of energy expenditure and thermogenesis in the hypothalamus with targeted manipulation techniques of the mouse genome and neuronal function. In this review, we elucidate recent progress in understanding the mechanism of how the hypothalamus affects basal metabolism, modulates physical activity, and adapts to environmental temperature and food intake changes.

Original languageEnglish
Pages (from-to)358-369
Number of pages12
JournalExperimental and Molecular Medicine
Issue number4
Publication statusPublished - 2022 Apr

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry


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