Hydrogen Bonding Nanoarchitectonics of Organic Pigment-Based Janus Microrobots with Entering Capability into Cancer Cells

Anna Jancik-Prochazkova, Hana Michalkova, Zbynek Heger, Martin Pumera

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Autonomous microrobots are at the forefront of biomedical research as they are expected to be applied for specific tasks at the intracellular level such as cargo delivery, sensing, molecular manipulation, among others. Here, we report on a preparation of microrobots based on quinacridone and indigo, which are members of the organic hydrogen-bonded pigment family. The microrobots were fabricated by asymmetric platinum deposition on corresponding quinacridone and indigo microparticles that possessed a homogeneous size and shape distribution. The microrobots exhibited autonomous locomotion in the presence of hydrogen peroxide, which was further supported by UV irradiation. The organic pigment-based microrobots were studied in the presence of mouse colorectal carcinoma cells, and it was observed that they were internalized into the cells. Internalization was visualized using confocal laser scanning microscopy. This study reveals the possibility of fabricating hydrogen-bonded organic pigment-based microrobots for biomedical applications by employing the principles of nanoarchitectonics.

Original languageEnglish
Pages (from-to)146-156
Number of pages11
JournalACS Nano
Volume17
Issue number1
DOIs
Publication statusPublished - 2023 Jan 10

Bibliographical note

Publisher Copyright:
© 2022 American Chemical Society.

All Science Journal Classification (ASJC) codes

  • General Materials Science
  • General Engineering
  • General Physics and Astronomy

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