Hydroacylation of 4-[18F]fluorobenzaldehyde: A novel method for the preparation of 4′-[18F]phenylketones

Noor Ul Hasan Khan; Byung Chul Lee; Sang Yoon Lee; Yearn Seong Choe; Chul Ho Jun; Dae Yoon Chi

doi:10.1002/jlcr.623

Hydroacylation of 4-[¹⁸F]fluorobenzaldehyde: A novel method for the preparation of 4′-[^18F]phenylketones

Noor Ul Hasan Khan, Byung Chul Lee, Sang Yoon Lee, Yearn Seong Choe, Chul Ho Jun, Dae Yoon Chi

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

To assess the potential of intermolecular hydroacylation reactions as a new fluorine-18 labeling method, model reactions of [¹⁸F]fluorobenzaldehyde with three different olefins (1-hexene (2a), allylbenzene (2b), and 3-phenoxypropene (2c)) in the presence of Wilkinson's catalyst were performed. The procedure gave high radiochemical yields (38-62%) of [¹⁸F]fluorophenylketones with short reaction times (15 min). The intermolecular hydroacylation reaction provides a new method for the preparation of fluorine-18 labeled compounds.

Original language	English
Pages (from-to)	1045-1053
Number of pages	9
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	45
Issue number	12
DOIs	https://doi.org/10.1002/jlcr.623
Publication status	Published - 2002 Oct 30

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Radiology Nuclear Medicine and imaging
Drug Discovery
Spectroscopy
Organic Chemistry

Access to Document

10.1002/jlcr.623

Cite this

@article{85cb3268e694429b903587bfc529d3ac,

title = "Hydroacylation of 4-[18F]fluorobenzaldehyde: A novel method for the preparation of 4′-[18F]phenylketones",

abstract = "To assess the potential of intermolecular hydroacylation reactions as a new fluorine-18 labeling method, model reactions of [18F]fluorobenzaldehyde with three different olefins (1-hexene (2a), allylbenzene (2b), and 3-phenoxypropene (2c)) in the presence of Wilkinson's catalyst were performed. The procedure gave high radiochemical yields (38-62%) of [18F]fluorophenylketones with short reaction times (15 min). The intermolecular hydroacylation reaction provides a new method for the preparation of fluorine-18 labeled compounds.",

author = "Khan, {Noor Ul Hasan} and Lee, {Byung Chul} and Lee, {Sang Yoon} and Choe, {Yearn Seong} and Jun, {Chul Ho} and Chi, {Dae Yoon}",

year = "2002",

month = oct,

day = "30",

doi = "10.1002/jlcr.623",

language = "English",

volume = "45",

pages = "1045--1053",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "John Wiley and Sons Ltd",

number = "12",

}

TY - JOUR

T1 - Hydroacylation of 4-[18F]fluorobenzaldehyde

T2 - A novel method for the preparation of 4′-[18F]phenylketones

AU - Khan, Noor Ul Hasan

AU - Lee, Byung Chul

AU - Lee, Sang Yoon

AU - Choe, Yearn Seong

AU - Jun, Chul Ho

AU - Chi, Dae Yoon

PY - 2002/10/30

Y1 - 2002/10/30

N2 - To assess the potential of intermolecular hydroacylation reactions as a new fluorine-18 labeling method, model reactions of [18F]fluorobenzaldehyde with three different olefins (1-hexene (2a), allylbenzene (2b), and 3-phenoxypropene (2c)) in the presence of Wilkinson's catalyst were performed. The procedure gave high radiochemical yields (38-62%) of [18F]fluorophenylketones with short reaction times (15 min). The intermolecular hydroacylation reaction provides a new method for the preparation of fluorine-18 labeled compounds.

AB - To assess the potential of intermolecular hydroacylation reactions as a new fluorine-18 labeling method, model reactions of [18F]fluorobenzaldehyde with three different olefins (1-hexene (2a), allylbenzene (2b), and 3-phenoxypropene (2c)) in the presence of Wilkinson's catalyst were performed. The procedure gave high radiochemical yields (38-62%) of [18F]fluorophenylketones with short reaction times (15 min). The intermolecular hydroacylation reaction provides a new method for the preparation of fluorine-18 labeled compounds.

UR - http://www.scopus.com/inward/record.url?scp=0037202349&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037202349&partnerID=8YFLogxK

U2 - 10.1002/jlcr.623

DO - 10.1002/jlcr.623

M3 - Article

AN - SCOPUS:0037202349

SN - 0362-4803

VL - 45

SP - 1045

EP - 1053

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 12

ER -

Hydroacylation of 4-[¹⁸F]fluorobenzaldehyde: A novel method for the preparation of 4′-[^18F]phenylketones

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this