Hydrazinocurcumin, a novel synthetic curcumin derivative, Is a potent inhibitor of endothelial cell proliferation

Joong Sup Shim; Dong Hoon Kim; Hye Jin Jung; Jin Hee Kim; Dongyeol Lim; Seok Ki Lee; Kyu Won Kim; Jong Woong Ahn; Jong Shin Yoo; Jung Rae Rho; Jongheon Shin; Ho Jeong Kwon

doi:10.1016/S0968-0896(02)00116-5

Hydrazinocurcumin, a novel synthetic curcumin derivative, Is a potent inhibitor of endothelial cell proliferation

Joong Sup Shim, Dong Hoon Kim, Hye Jin Jung, Jin Hee Kim, Dongyeol Lim, Seok Ki Lee, Kyu Won Kim, Jong Woong Ahn, Jong Shin Yoo, Jung Rae Rho, Jongheon Shin, Ho Jeong Kwon

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC₅₀=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.

Original language	English
Pages (from-to)	2439-2444
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	10
Issue number	8
DOIs	https://doi.org/10.1016/S0968-0896(02)00116-5
Publication status	Published - 2002

Bibliographical note

Funding Information:
This work was supported by a grant to HJK from Korea Health 21 R&D Project, Ministry of Health & Welfare (HMP-01-PJ1-PG1–01CH04–0005) and to JS from the Ministry of Science and Technology of Korea (PN 99384). We are grateful to Dr. Jo at the KNIH for BAECs.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Sup Shim, J., Hoon Kim, D., Jung, H. J., Hee Kim, J., Lim, D., Lee, S. K., Kim, K. W., Ahn, J. W., Yoo, J. S., Rho, J. R., Shin, J., & Jeong Kwon, H. (2002). Hydrazinocurcumin, a novel synthetic curcumin derivative, Is a potent inhibitor of endothelial cell proliferation. Bioorganic and Medicinal Chemistry, 10(8), 2439-2444. https://doi.org/10.1016/S0968-0896(02)00116-5

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abstract = "Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC50=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.",

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note = "Funding Information: This work was supported by a grant to HJK from Korea Health 21 R&D Project, Ministry of Health & Welfare (HMP-01-PJ1-PG1–01CH04–0005) and to JS from the Ministry of Science and Technology of Korea (PN 99384). We are grateful to Dr. Jo at the KNIH for BAECs.",

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doi = "10.1016/S0968-0896(02)00116-5",

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AU - Sup Shim, Joong

AU - Hoon Kim, Dong

AU - Jung, Hye Jin

AU - Hee Kim, Jin

AU - Lim, Dongyeol

AU - Lee, Seok Ki

AU - Kim, Kyu Won

AU - Ahn, Jong Woong

AU - Yoo, Jong Shin

AU - Rho, Jung Rae

AU - Shin, Jongheon

AU - Jeong Kwon, Ho

N1 - Funding Information: This work was supported by a grant to HJK from Korea Health 21 R&D Project, Ministry of Health & Welfare (HMP-01-PJ1-PG1–01CH04–0005) and to JS from the Ministry of Science and Technology of Korea (PN 99384). We are grateful to Dr. Jo at the KNIH for BAECs.

PY - 2002

Y1 - 2002

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AB - Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC50=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.

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Hydrazinocurcumin, a novel synthetic curcumin derivative, Is a potent inhibitor of endothelial cell proliferation

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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