Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging

Eun Kyung Lim; Hyun Ouk Kim; Eunji Jang; Joseph Park; Kwangyeol Lee; Jin Suck Suh; Yong Min Huh; Seungjoo Haam

doi:10.1016/j.biomaterials.2011.06.077

Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging

Eun Kyung Lim, Hyun Ouk Kim, Eunji Jang, Joseph Park, Kwangyeol Lee, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journal › Article › peer-review

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Abstract

We fabricated hyaluronan-modified magnetic nanoclusters (HA-MNCs) for detection of CD44-overexpressing breast cancer using magnetic resonance (MR) imaging. CD44 is closely associated with cancer growth, including proliferation, metastasis, invasion, and angiogenesis. Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Subsequently, HA-MNCs were fabricated using the nano-emulsion method; magnetic nanocrystals were simultaneously self-assembled with Py-HA conjugates, and their physical and magnetic properties depended on the degree of substitution (DS) of Py in Py-HA conjugates. HA-MNCs exhibited superior targeting efficiency with MR sensitivity as well as excellent biocompatibility through in vitro/in vivo studies. This suggests that HA-MNCs can be a potent cancer specific molecular imaging agent via targeted detection of CD44 with MR imaging.

Original language	English
Pages (from-to)	7941-7950
Number of pages	10
Journal	Biomaterials
Volume	32
Issue number	31
DOIs	https://doi.org/10.1016/j.biomaterials.2011.06.077
Publication status	Published - 2011 Nov

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea ( A085136 ).

All Science Journal Classification (ASJC) codes

Biophysics
Bioengineering
Ceramics and Composites
Biomaterials
Mechanics of Materials

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2011.06.077

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title = "Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging",

abstract = "We fabricated hyaluronan-modified magnetic nanoclusters (HA-MNCs) for detection of CD44-overexpressing breast cancer using magnetic resonance (MR) imaging. CD44 is closely associated with cancer growth, including proliferation, metastasis, invasion, and angiogenesis. Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Subsequently, HA-MNCs were fabricated using the nano-emulsion method; magnetic nanocrystals were simultaneously self-assembled with Py-HA conjugates, and their physical and magnetic properties depended on the degree of substitution (DS) of Py in Py-HA conjugates. HA-MNCs exhibited superior targeting efficiency with MR sensitivity as well as excellent biocompatibility through in vitro/in vivo studies. This suggests that HA-MNCs can be a potent cancer specific molecular imaging agent via targeted detection of CD44 with MR imaging.",

author = "Lim, {Eun Kyung} and Kim, {Hyun Ouk} and Eunji Jang and Joseph Park and Kwangyeol Lee and Suh, {Jin Suck} and Huh, {Yong Min} and Seungjoo Haam",

note = "Funding Information: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea ( A085136 ).",

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AU - Park, Joseph

AU - Lee, Kwangyeol

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Haam, Seungjoo

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N2 - We fabricated hyaluronan-modified magnetic nanoclusters (HA-MNCs) for detection of CD44-overexpressing breast cancer using magnetic resonance (MR) imaging. CD44 is closely associated with cancer growth, including proliferation, metastasis, invasion, and angiogenesis. Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Subsequently, HA-MNCs were fabricated using the nano-emulsion method; magnetic nanocrystals were simultaneously self-assembled with Py-HA conjugates, and their physical and magnetic properties depended on the degree of substitution (DS) of Py in Py-HA conjugates. HA-MNCs exhibited superior targeting efficiency with MR sensitivity as well as excellent biocompatibility through in vitro/in vivo studies. This suggests that HA-MNCs can be a potent cancer specific molecular imaging agent via targeted detection of CD44 with MR imaging.

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Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging

Abstract

Bibliographical note

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