Hormonal activity of AIMP1/p43 for glucose homeostasis

Sang Gyu Park; Young Sun Kang; Jin Young Kim; Chang Seok Lee; Young Gyu Ko; Woo Je Lee; Ki Up Lee; Young Il Yeom; Sunghoon Kim

doi:10.1073/pnas.0602045103

Hormonal activity of AIMP1/p43 for glucose homeostasis

Sang Gyu Park, Young Sun Kang, Jin Young Kim, Chang Seok Lee, Young Gyu Ko, Woo Je Lee, Ki Up Lee, Young Il Yeom, Sunghoon Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.

Original language	English
Pages (from-to)	14913-14918
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	103
Issue number	40
DOIs	https://doi.org/10.1073/pnas.0602045103
Publication status	Published - 2006 Oct 3

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title = "Hormonal activity of AIMP1/p43 for glucose homeostasis",

abstract = "AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.",

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AU - Park, Sang Gyu

AU - Kang, Young Sun

AU - Kim, Jin Young

AU - Lee, Chang Seok

AU - Ko, Young Gyu

AU - Lee, Woo Je

AU - Lee, Ki Up

AU - Yeom, Young Il

AU - Kim, Sunghoon

PY - 2006/10/3

Y1 - 2006/10/3

N2 - AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.

AB - AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.

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Hormonal activity of AIMP1/p43 for glucose homeostasis

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