HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea

Min Hyung Kim; Je Eun Song; Jin Young Ahn; Yong Chan Kim; Dong Hyun Oh; Heun Choi; Hea Won Ann; Jae Kyoung Kim; Sun Bean Kim; Su Jin Jeong; Nam Su Ku; Sang Hoon Han; Young Goo Song; June Myung Kim; Jun Yong Choi

doi:10.1089/aid.2013.0184

HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea

Min Hyung Kim, Je Eun Song, Jin Young Ahn, Yong Chan Kim, Dong Hyun Oh, Heun Choi, Hea Won Ann, Jae Kyoung Kim, Sun Bean Kim, Su Jin Jeong, Nam Su Ku, Sang Hoon Han, Young Goo Song, June Myung Kim, Jun Yong Choi

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea.

Original language	English
Pages (from-to)	1617-1620
Number of pages	4
Journal	AIDS Research and Human Retroviruses
Volume	29
Issue number	12
DOIs	https://doi.org/10.1089/aid.2013.0184
Publication status	Published - 2013 Dec 1

All Science Journal Classification (ASJC) codes

Infectious Diseases
Virology
Immunology

UN SDGs

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10.1089/aid.2013.0184

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Kim, M. H., Song, J. E., Ahn, J. Y., Kim, Y. C., Oh, D. H., Choi, H., Ann, H. W., Kim, J. K., Kim, S. B., Jeong, S. J., Ku, N. S., Han, S. H., Song, Y. G., Kim, J. M., & Choi, J. Y. (2013). HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea. AIDS Research and Human Retroviruses, 29(12), 1617-1620. https://doi.org/10.1089/aid.2013.0184

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title = "HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea",

abstract = "The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea.",

author = "Kim, {Min Hyung} and Song, {Je Eun} and Ahn, {Jin Young} and Kim, {Yong Chan} and Oh, {Dong Hyun} and Heun Choi and Ann, {Hea Won} and Kim, {Jae Kyoung} and Kim, {Sun Bean} and Jeong, {Su Jin} and Ku, {Nam Su} and Han, {Sang Hoon} and Song, {Young Goo} and Kim, {June Myung} and Choi, {Jun Yong}",

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Kim, MH, Song, JE, Ahn, JY, Kim, YC, Oh, DH, Choi, H, Ann, HW, Kim, JK, Kim, SB, Jeong, SJ, Ku, NS, Han, SH, Song, YG, Kim, JM & Choi, JY 2013, 'HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea', AIDS Research and Human Retroviruses, vol. 29, no. 12, pp. 1617-1620. https://doi.org/10.1089/aid.2013.0184

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AU - Oh, Dong Hyun

AU - Choi, Heun

AU - Ann, Hea Won

AU - Kim, Jae Kyoung

AU - Kim, Sun Bean

AU - Jeong, Su Jin

AU - Ku, Nam Su

AU - Han, Sang Hoon

AU - Song, Young Goo

AU - Kim, June Myung

AU - Choi, Jun Yong

PY - 2013/12/1

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N2 - The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea.

AB - The purpose of this study was to assess the prevalence and characteristics of HIV drug resistance mutations among antiretroviral therapy (ART)-naive and ART-experienced patients in South Korea. A total of 50 ART-naive and 34 ART-experienced Korean HIV-1-infected patients who visited an urban hospital from February 2007 to March 2011 were included. Most patients (86.9%) were infected with clade B HIV-1. Six (12%) ART-naive and 22 (64.7%) ART-experienced patients had HIV strains with resistance mutations. Among ART-naive patients, V179D was the most common mutation, being found in five ART-naive patients. Among ART-experienced patients, M184V was the most common mutation. Eight of 34 ART-experienced patients had thymidine analogue mutations (TAMs). The prevalence of drug-resistant HIV-1 in ART-naive patients was higher than in previous reports, and 50% of patients with virologic failure harbored strains with multiple resistance mutations. HIV drug resistance testing should be recommended to guide therapy of ART-naive patients in South Korea.

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HIV Antiretroviral Resistance Mutations among Antiretroviral Treatment-Naive and-Experienced Patients in South Korea

Abstract

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