Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing

Mee Young Ahn; Dong O. Kang; Yong Jin Na; Sungpil Yoon; Whan Soo Choi; Keun Wook Kang; Hae Young Chung; Jee H. Jung; Do Sik Min; Hyung Sik Kim

doi:10.1016/j.canlet.2012.06.017

Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing

Mee Young Ahn, Dong O. Kang, Yong Jin Na, Sungpil Yoon, Whan Soo Choi, Keun Wook Kang, Hae Young Chung, Jee H. Jung, Do Sik Min, Hyung Sik Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

This study examined the molecular mechanisms of apicidin in the modulation of human ovarian cancer SKOV-3 cells invasion and migration. Apicidin markedly decreased histone deacetylase 4 (HDAC4) expression and blocked cell migration and invasion. Cell migration was inhibited via down-regulation of matrix metalloproteinase-2 (MMP-2) and up-regulation of RECK in the HDAC4-blocked SKOV-3 cells. Apicidin significantly suppressed the binding of HDAC4 to Sp1 binding elements of the RECK promoter via repression of HDAC4. In an in vivo model, apicidin suppressed the growth of transplanted SKOV-3 cells by down-regulating HDAC4 and MMP-2. Apicidin may potentially be used as an anti-cancer agent for inhibition of cancer cell migration and invasion through the repression of MMP-2 which is related to the reduction of HDAC4.

Original language	English
Pages (from-to)	189-199
Number of pages	11
Journal	Cancer Letters
Volume	325
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2012.06.017
Publication status	Published - 2012 Dec 28

Bibliographical note

Funding Information:
This work was supported by National Research Foundation of Korea (NRF) grants funded by the Korea government (No. 20090083538, KRF-2008-314-E00292, and No. 2011-0023907).

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2012.06.017

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title = "Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing",

abstract = "This study examined the molecular mechanisms of apicidin in the modulation of human ovarian cancer SKOV-3 cells invasion and migration. Apicidin markedly decreased histone deacetylase 4 (HDAC4) expression and blocked cell migration and invasion. Cell migration was inhibited via down-regulation of matrix metalloproteinase-2 (MMP-2) and up-regulation of RECK in the HDAC4-blocked SKOV-3 cells. Apicidin significantly suppressed the binding of HDAC4 to Sp1 binding elements of the RECK promoter via repression of HDAC4. In an in vivo model, apicidin suppressed the growth of transplanted SKOV-3 cells by down-regulating HDAC4 and MMP-2. Apicidin may potentially be used as an anti-cancer agent for inhibition of cancer cell migration and invasion through the repression of MMP-2 which is related to the reduction of HDAC4.",

author = "Ahn, {Mee Young} and Kang, {Dong O.} and Na, {Yong Jin} and Sungpil Yoon and Choi, {Whan Soo} and Kang, {Keun Wook} and Chung, {Hae Young} and Jung, {Jee H.} and Min, {Do Sik} and Kim, {Hyung Sik}",

note = "Funding Information: This work was supported by National Research Foundation of Korea (NRF) grants funded by the Korea government (No. 20090083538, KRF-2008-314-E00292, and No. 2011-0023907). ",

year = "2012",

month = dec,

day = "28",

doi = "10.1016/j.canlet.2012.06.017",

language = "English",

volume = "325",

pages = "189--199",

journal = "Cancer Letters",

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T1 - Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing

AU - Ahn, Mee Young

AU - Kang, Dong O.

AU - Na, Yong Jin

AU - Yoon, Sungpil

AU - Choi, Whan Soo

AU - Kang, Keun Wook

AU - Chung, Hae Young

AU - Jung, Jee H.

AU - Min, Do Sik

AU - Kim, Hyung Sik

N1 - Funding Information: This work was supported by National Research Foundation of Korea (NRF) grants funded by the Korea government (No. 20090083538, KRF-2008-314-E00292, and No. 2011-0023907).

PY - 2012/12/28

Y1 - 2012/12/28

N2 - This study examined the molecular mechanisms of apicidin in the modulation of human ovarian cancer SKOV-3 cells invasion and migration. Apicidin markedly decreased histone deacetylase 4 (HDAC4) expression and blocked cell migration and invasion. Cell migration was inhibited via down-regulation of matrix metalloproteinase-2 (MMP-2) and up-regulation of RECK in the HDAC4-blocked SKOV-3 cells. Apicidin significantly suppressed the binding of HDAC4 to Sp1 binding elements of the RECK promoter via repression of HDAC4. In an in vivo model, apicidin suppressed the growth of transplanted SKOV-3 cells by down-regulating HDAC4 and MMP-2. Apicidin may potentially be used as an anti-cancer agent for inhibition of cancer cell migration and invasion through the repression of MMP-2 which is related to the reduction of HDAC4.

AB - This study examined the molecular mechanisms of apicidin in the modulation of human ovarian cancer SKOV-3 cells invasion and migration. Apicidin markedly decreased histone deacetylase 4 (HDAC4) expression and blocked cell migration and invasion. Cell migration was inhibited via down-regulation of matrix metalloproteinase-2 (MMP-2) and up-regulation of RECK in the HDAC4-blocked SKOV-3 cells. Apicidin significantly suppressed the binding of HDAC4 to Sp1 binding elements of the RECK promoter via repression of HDAC4. In an in vivo model, apicidin suppressed the growth of transplanted SKOV-3 cells by down-regulating HDAC4 and MMP-2. Apicidin may potentially be used as an anti-cancer agent for inhibition of cancer cell migration and invasion through the repression of MMP-2 which is related to the reduction of HDAC4.

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JO - Cancer Letters

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Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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