High-dose versus standard-dose radiation therapy for cervical esophageal cancer: Retrospective single-institution study

Tae Hyung Kim; Ik Jae Lee; Ji Hyun Kim; Chang Geol Lee; Yong Chan Lee; Jun Won Kim

doi:10.1002/hed.25483

High-dose versus standard-dose radiation therapy for cervical esophageal cancer: Retrospective single-institution study

Tae Hyung Kim, Ik Jae Lee, Ji Hyun Kim, Chang Geol Lee, Yong Chan Lee, Jun Won Kim

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Background: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE). Methods: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59.4 Gy, n = 44) and standard-dose (<59.4 Gy, n = 35) groups. Results: The median follow-up was 35 months for surviving patients. The high-dose group had significantly better 3-year local (90.0% vs 60.4%, P =.001) and locoregional (70.4% vs 45.3%, P =.04) control. Progression-free (45.4% vs 37.5%, P =.32) and overall (58.4% vs 49.1%, P =.69) survival rates were not different. High-dose radiation was an independent prognostic factor for locoregional control (P =.04). No differences in late toxicities (esophageal stenosis or tracheoesophageal fistula) were observed. Conclusion: High-dose radiation for CCE improves local and locoregional control, without increasing severe toxicities.

Original language	English
Pages (from-to)	146-153
Number of pages	8
Journal	Head and Neck
Volume	41
Issue number	1
DOIs	https://doi.org/10.1002/hed.25483
Publication status	Published - 2019 Jan

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Republic of Korea, Grant/ Award Number: (2017R1D1A1B03035047); Korean Health Industry Development Institute funded by the Ministry of Health and Welfare, Republic of Korea, Grant/Award Number: (HI15C0638)

Publisher Copyright:
© 2018 Wiley Periodicals, Inc.

All Science Journal Classification (ASJC) codes

Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "High-dose versus standard-dose radiation therapy for cervical esophageal cancer: Retrospective single-institution study",

abstract = "Background: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE). Methods: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59.4 Gy, n = 44) and standard-dose (<59.4 Gy, n = 35) groups. Results: The median follow-up was 35 months for surviving patients. The high-dose group had significantly better 3-year local (90.0% vs 60.4%, P =.001) and locoregional (70.4% vs 45.3%, P =.04) control. Progression-free (45.4% vs 37.5%, P =.32) and overall (58.4% vs 49.1%, P =.69) survival rates were not different. High-dose radiation was an independent prognostic factor for locoregional control (P =.04). No differences in late toxicities (esophageal stenosis or tracheoesophageal fistula) were observed. Conclusion: High-dose radiation for CCE improves local and locoregional control, without increasing severe toxicities.",

author = "Kim, {Tae Hyung} and Lee, {Ik Jae} and Kim, {Ji Hyun} and Lee, {Chang Geol} and Lee, {Yong Chan} and Kim, {Jun Won}",

note = "Funding Information: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Republic of Korea, Grant/ Award Number: (2017R1D1A1B03035047); Korean Health Industry Development Institute funded by the Ministry of Health and Welfare, Republic of Korea, Grant/Award Number: (HI15C0638) Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

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AU - Lee, Chang Geol

AU - Lee, Yong Chan

AU - Kim, Jun Won

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PY - 2019/1

Y1 - 2019/1

N2 - Background: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE). Methods: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59.4 Gy, n = 44) and standard-dose (<59.4 Gy, n = 35) groups. Results: The median follow-up was 35 months for surviving patients. The high-dose group had significantly better 3-year local (90.0% vs 60.4%, P =.001) and locoregional (70.4% vs 45.3%, P =.04) control. Progression-free (45.4% vs 37.5%, P =.32) and overall (58.4% vs 49.1%, P =.69) survival rates were not different. High-dose radiation was an independent prognostic factor for locoregional control (P =.04). No differences in late toxicities (esophageal stenosis or tracheoesophageal fistula) were observed. Conclusion: High-dose radiation for CCE improves local and locoregional control, without increasing severe toxicities.

AB - Background: To evaluate the role of definitive radiotherapy using higher-than-standard-dose radiation of 50 Gy for carcinoma of the cervical esophagus (CCE). Methods: We reviewed 79 patients with stage I-III CCE, treated between 2000 and 2012. Patients received 5-fluorouracil/cisplatin-based chemotherapy concurrently and were divided into high-dose (≥59.4 Gy, n = 44) and standard-dose (<59.4 Gy, n = 35) groups. Results: The median follow-up was 35 months for surviving patients. The high-dose group had significantly better 3-year local (90.0% vs 60.4%, P =.001) and locoregional (70.4% vs 45.3%, P =.04) control. Progression-free (45.4% vs 37.5%, P =.32) and overall (58.4% vs 49.1%, P =.69) survival rates were not different. High-dose radiation was an independent prognostic factor for locoregional control (P =.04). No differences in late toxicities (esophageal stenosis or tracheoesophageal fistula) were observed. Conclusion: High-dose radiation for CCE improves local and locoregional control, without increasing severe toxicities.

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High-dose versus standard-dose radiation therapy for cervical esophageal cancer: Retrospective single-institution study

Abstract

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UN SDGs

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