Hepatitis B Core-Related Antigen: From Virology to Clinical Application

Hye Won Lee; Sang Hoon Ahn; Henry Lik Yuen Chan

doi:10.1055/s-0041-1723088

Hepatitis B Core-Related Antigen: From Virology to Clinical Application

Hye Won Lee, Sang Hoon Ahn, Henry Lik Yuen Chan

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Hepatitis B core-related antigen (HBcrAg) is a composite measure of the serum levels of hepatitis B e antigen, hepatitis B core antigen, and a 22-kDa precore protein. It has been shown to reflect the level and transcriptional activity of covalently closed circular DNA in the liver. Longitudinal cohort studies have improved our understanding of the role of this novel viral marker in the natural history of chronic hepatitis B. HBcrAg kinetics reflect the response to peginterferon, and its role in defining guidelines for stopping peginterferon therapy has been evaluated. HBcrAg is a marker of intrahepatic viral activity, which may influence the risk of hepatocellular carcinoma. In this article, we review the virology and role of HBcrAg in defining phases of chronic hepatitis B. Furthermore, the function of HBcrAg in predicting treatment outcomes and its role in monitoring response to novel antiviral agents will be discussed.

Original language	English
Pages (from-to)	182-190
Number of pages	9
Journal	Seminars in Liver Disease
Volume	41
Issue number	2
DOIs	https://doi.org/10.1055/s-0041-1723088
Publication status	Published - 2021 May 1

Bibliographical note

Publisher Copyright:
© 2021 Thieme Medical Publishers, Inc.. All rights reserved.

All Science Journal Classification (ASJC) codes

Hepatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-0041-1723088

Cite this

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abstract = "Hepatitis B core-related antigen (HBcrAg) is a composite measure of the serum levels of hepatitis B e antigen, hepatitis B core antigen, and a 22-kDa precore protein. It has been shown to reflect the level and transcriptional activity of covalently closed circular DNA in the liver. Longitudinal cohort studies have improved our understanding of the role of this novel viral marker in the natural history of chronic hepatitis B. HBcrAg kinetics reflect the response to peginterferon, and its role in defining guidelines for stopping peginterferon therapy has been evaluated. HBcrAg is a marker of intrahepatic viral activity, which may influence the risk of hepatocellular carcinoma. In this article, we review the virology and role of HBcrAg in defining phases of chronic hepatitis B. Furthermore, the function of HBcrAg in predicting treatment outcomes and its role in monitoring response to novel antiviral agents will be discussed.",

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Hepatitis B Core-Related Antigen: From Virology to Clinical Application

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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